Pathogenesis and Prevention of Intraventricular Hemorrhage

被引：211

作者：

Ballabh, Praveen ^{[1
]}

机构：

[1] Maria Fareri Childrens Hosp, New York Med Coll, Westchester Med Ctr, Dept Pediat Cell Biol & Anat,Reg Neonatal Ctr, Valhalla, NY 10595 USA

来源：

CLINICS IN PERINATOLOGY | 2014年 / 41卷 / 01期

关键词：

Germinal matrix hemorrhage; Intraventricular hemorrhage; Astrocytes; Pericytes; Angiogenesis; Glucocorticoids; Premature infants; Indomethacin; CEREBRAL-BLOOD-FLOW; BIRTH-WEIGHT INFANTS; FACTOR-V-LEIDEN; GERMINAL MATRIX; PRETERM INFANTS; PREMATURE-INFANTS; PERIVENTRICULAR HEMORRHAGE; INTRACRANIAL HEMORRHAGE; BRAIN-BARRIER; WHITE-MATTER;

D O I：

10.1016/j.clp.2013.09.007

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

Intraventricular hemorrhage (IVH) is a major neurologic complication of prematurity. Pathogenesis of IVH is attributed to intrinsic fragility of germinal matrix vasculature and to the fluctuation in the cerebral blood flow. Germinal matrix exhibits rapid angiogenesis orchestrating formation of immature vessels. Prenatal glucocorticoid exposure remains the most effective means of preventing IVH. Therapies targeted to enhance the stability of the germinal matrix vasculature and minimize fluctuation in the cerebral blood flow might lead to more effective strategies in preventing IVH.

引用

页码：47 / +

页数：23

共 126 条

[1] The TNF-α-308, MCP-1-2518 and TGF-β1+915 polymorphisms are not associated with the development of chronic lung disease in very low birth weight infants [J].