MicroRNA in Ovarian Biology and Disease

被引：44

作者：

McGinnis, Lynda K. ^{[1
]}

Luense, Lacey J. ^{[2
]}

Christenson, Lane K. ^{[1
]}

机构：

[1] Univ Kansas, Med Ctr, Dept Mol & Integrat Physiol, Kansas City, KS 66160 USA

[2] Univ Penn, Perelman Sch Med, Dept Cell & Dev Biol, Epigenet Program, Philadelphia, PA 19104 USA

来源：

COLD SPRING HARBOR PERSPECTIVES IN MEDICINE | 2015年 / 5卷 / 09期

关键词：

GRANULOSA-CELL PROLIFERATION; RECEPTOR MESSENGER-RNA; GENE-EXPRESSION; FOLLICULAR DEVELOPMENT; ENDOGENOUS SIRNAS; FEMALE FERTILITY; BINDING-PROTEIN; POTENTIAL ROLE; MOUSE; IDENTIFICATION;

D O I：

10.1101/cshperspect.a022962

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

MicroRNAs (miRNAs) are posttranscriptional gene regulatory molecules that show regulated expression within ovarian tissue. Most research investigating miRNAs in the ovary has relied exclusively on in vitro analyses. In this review, we highlight those few studies in which investigators have illustrated an in vivo effect of miRNAs on ovarian function. We also provide a synopsis of how these small noncoding RNAs can impact ovarian disease. miRNAs have great potential as novel diagnostic biomarkers for the detection of ovarian disease and in the assisted reproductive technologies (ART) for selection of healthy viable oocytes and embryos.

引用

页数：19

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