After surviving cancer, what about late life effects of the cure?

被引：30

作者：

Nonnekens, Julie ^{[1
]}

Hoeijmakers, Jan H. J. ^{[1
]}

机构：

[1] Erasmus MC, Dept Mol Genet, Rotterdam, Netherlands

来源：

EMBO MOLECULAR MEDICINE | 2017年 / 9卷 / 01期

关键词：

DNA-DAMAGE; DISEASE;

D O I：

10.15252/emmm.201607062

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

The widely used chemotherapeutic cisplatin causes ototoxicity as late-term side effect. In this issue, Benkafadar etal () decipher the mechanism of cisplatin-induced ototoxicity and provide evidence that transient inhibition of p53 ameliorates ototoxicity without influencing chemotherapeutic efficacy. These findings may open exciting perspectives for reducing (late-term) side effects of cancer treatment.

引用

收藏

页码：4 / 6

页数：3

相关论文

共 10 条

[1] Aging and Risk of Severe, Disabling, Life-Threatening, and Fatal Events in the Childhood Cancer Survivor Study [J].

Armstrong, Gregory T. ;

Kawashima, Toana ;

Leisenring, Wendy ;

Stratton, Kayla ;

Stovall, Marilyn ;

Hudson, Melissa M. ;

Sklar, Charles A. ;

Robison, Leslie L. ;

Oeffinger, Kevin C. .

JOURNAL OF CLINICAL ONCOLOGY, 2014, 32 (12) :1218-+

[2] Reversible p53 inhibition prevents cisplatinototoxicity without blocking chemotherapeutic efficacy [J].

Benkafadar, Nesrine ;

Menardo, Julien ;

Bourien, Jerome ;

Nouvian, Regis ;

Francois, Florence ;

Decaudin, Didier ;

Maiorano, Domenico ;

Puel, Jean-Luc ;

Wang, Jing .

EMBO MOLECULAR MEDICINE, 2017, 9 (01) :7-26

[3]

Brandhorst S, 2016, RECENT RESULTS CANC, V207, P241, DOI 10.1007/978-3-319-42118-6_12

[4] Cellular senescence in aging and age-related disease: from mechanisms to therapy [J].

Childs, Bennett G. ;

Durik, Matej ;

Baker, Darren J. ;

van Deursen, Jan M. .

NATURE MEDICINE, 2015, 21 (12) :1424-1435

[5] Declining p53 function in the aging process: A possible mechanism for the increased tumor incidence in older populations [J].

Feng, Zhaohui ;

Hu, Wenwei ;

Teresky, Angelika K. ;

Hernando, Eva ;

Cordon-Cardo, Carlos ;

Levine, Arnold J. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2007, 104 (42) :16633-16638

[6]

Fram Robert J., 1992, Current Opinion in Oncology, V4, P1073, DOI 10.1097/00001622-199212000-00012

[7] MOLECULAR ORIGINS OF CANCER DNA Damage, Aging, and Cancer [J].

Hoeijmakers, Jan H. J. .

NEW ENGLAND JOURNAL OF MEDICINE, 2009, 361 (15) :1475-1485

[8] The DNA-damage response in human biology and disease [J].

Jackson, Stephen P. ;

Bartek, Jiri .

NATURE, 2009, 461 (7267) :1071-1078

[9] Possible acceleration of aging by adjuvant chemotherapy: A cause of early onset frailty? [J].

Maccormick, Ronald Eric .

MEDICAL HYPOTHESES, 2006, 67 (02) :212-215

[10] The DNA damage-induced cell death response: a roadmap to kill cancer cells [J].

Matt, Sonja ;

Hofmann, Thomas G. .

CELLULAR AND MOLECULAR LIFE SCIENCES, 2016, 73 (15) :2829-2850