After surviving cancer, what about late life effects of the cure?

被引：28
作者：
Nonnekens, Julie [1 ]
Hoeijmakers, Jan H. J. [1 ]
机构：
[1] Erasmus MC, Dept Mol Genet, Rotterdam, Netherlands
来源：
EMBO MOLECULAR MEDICINE | 2017年 / 9卷 / 01期
关键词：
DNA-DAMAGE; DISEASE;
D O I：
10.15252/emmm.201607062
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
The widely used chemotherapeutic cisplatin causes ototoxicity as late-term side effect. In this issue, Benkafadar etal () decipher the mechanism of cisplatin-induced ototoxicity and provide evidence that transient inhibition of p53 ameliorates ototoxicity without influencing chemotherapeutic efficacy. These findings may open exciting perspectives for reducing (late-term) side effects of cancer treatment.
引用
收藏
页码：4 / 6
页数：3
相关论文
共 10 条
  • [1] Aging and Risk of Severe, Disabling, Life-Threatening, and Fatal Events in the Childhood Cancer Survivor Study
    Armstrong, Gregory T.
    Kawashima, Toana
    Leisenring, Wendy
    Stratton, Kayla
    Stovall, Marilyn
    Hudson, Melissa M.
    Sklar, Charles A.
    Robison, Leslie L.
    Oeffinger, Kevin C.
    [J]. JOURNAL OF CLINICAL ONCOLOGY, 2014, 32 (12) : 1218 - +
  • [2] Reversible p53 inhibition prevents cisplatinototoxicity without blocking chemotherapeutic efficacy
    Benkafadar, Nesrine
    Menardo, Julien
    Bourien, Jerome
    Nouvian, Regis
    Francois, Florence
    Decaudin, Didier
    Maiorano, Domenico
    Puel, Jean-Luc
    Wang, Jing
    [J]. EMBO MOLECULAR MEDICINE, 2017, 9 (01) : 7 - 26
  • [3] Brandhorst S, 2016, RECENT RESULTS CANC, V207, P241, DOI 10.1007/978-3-319-42118-6_12
  • [4] Cellular senescence in aging and age-related disease: from mechanisms to therapy
    Childs, Bennett G.
    Durik, Matej
    Baker, Darren J.
    van Deursen, Jan M.
    [J]. NATURE MEDICINE, 2015, 21 (12) : 1424 - 1435
  • [5] Declining p53 function in the aging process: A possible mechanism for the increased tumor incidence in older populations
    Feng, Zhaohui
    Hu, Wenwei
    Teresky, Angelika K.
    Hernando, Eva
    Cordon-Cardo, Carlos
    Levine, Arnold J.
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2007, 104 (42) : 16633 - 16638
  • [6] Fram Robert J., 1992, Current Opinion in Oncology, V4, P1073, DOI 10.1097/00001622-199212000-00012
  • [7] MOLECULAR ORIGINS OF CANCER DNA Damage, Aging, and Cancer
    Hoeijmakers, Jan H. J.
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 2009, 361 (15) : 1475 - 1485
  • [8] The DNA-damage response in human biology and disease
    Jackson, Stephen P.
    Bartek, Jiri
    [J]. NATURE, 2009, 461 (7267) : 1071 - 1078
  • [9] Possible acceleration of aging by adjuvant chemotherapy: A cause of early onset frailty?
    Maccormick, Ronald Eric
    [J]. MEDICAL HYPOTHESES, 2006, 67 (02) : 212 - 215
  • [10] The DNA damage-induced cell death response: a roadmap to kill cancer cells
    Matt, Sonja
    Hofmann, Thomas G.
    [J]. CELLULAR AND MOLECULAR LIFE SCIENCES, 2016, 73 (15) : 2829 - 2850
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