Pulmonary embolism: A complication of COVID 19 infection

被引:29
作者
Akel, Tamerf [1 ]
Qaqa, Firas [1 ]
Abuarqoub, Ahmad [1 ]
Shamoon, Fayez [1 ]
机构
[1] St Josephs Univ, Dept Cardiol, Med Ctr, 703 Main St, Paterson, NJ 07503 USA
关键词
Anticoagulation; Pulmonary embolism; Thrombolysis; COVID; 19;
D O I
10.1016/j.thromres.2020.05.033
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
The Coronavirus Disease 2019 (COVID 19) has been reported in almost every country in the world. Although a large proportion of infected individuals develop only mild symptoms or are asymptomatic, the spectrum of the disease among others has been widely variable in severity. Additionally, many infected individuals were found to have coagulation markers abnormalities. This is especially true among those progressing to severe pneumonia and multi-organ failure. While the incidence of venous thromboembolic (VTE) disease has been recently noted to be elevated among critically ill patients, the incidence among ambulatory and non-critically ill patients is not yet clearly defined. Herein, we present six patients who didn't have any hypercoagulable risk factors yet presented with pulmonary embolism in association with COVID 19 infection. Furthermore, we discuss the possible underlying mechanisms of hypercoagulability and highlight the possibility of underdiagnosing pulmonary embolism in the setting of overlapping symptoms, decreased utilization of imaging secondary to associated risks, and increased turnover times. In addition, we emphasize the role of extended thromboprophylaxis in discharged patients.
引用
收藏
页码:79 / 82
页数:4
相关论文
共 13 条
[1]  
[Anonymous], 2020, J THROMB HAEMOST, DOI DOI 10.1111/jth.14768
[2]  
[Anonymous], J THROMB HAEMOST, DOI DOI 10.1001/JAMA
[3]   Extended Thromboprophylaxis with Betrixaban in Acutely Ill Medical Patients [J].
Cohen, Alexander T. ;
Harrington, Robert A. ;
Goldhaber, Samuel Z. ;
Hull, Russell D. ;
Wiens, Brian L. ;
Gold, Alex ;
Hernandez, Adrian F. ;
Gibson, C. Michael ;
Cohen, Alexander ;
Harrington, Robert ;
Gibson, C. Michael ;
Hull, Russell ;
Goldhaber, Samuel ;
Hernandez, Adrian ;
Ceresetto, Jose Manuel ;
Colquhoun, David ;
Pilger, Ernst ;
Polonetsky, Leonid ;
Motte, Serge ;
Saraiva, Jose Francisco ;
Raev, Dimitar ;
Mincheva, Valentina ;
Kahn, Susan ;
Canon, Claudia Olivares ;
Malojcic, Branko ;
Mayer, Otto ;
Husted, Steen ;
Marandi, Toomas ;
Lassila, Riitta ;
Mottier, Dominique ;
Shaburishvili, Tamaz ;
Bauersachs, Rupert ;
Zeymer, Uwe ;
Hajko, Erik ;
Zeltser, David ;
Ageno, Walter ;
Krievins, Dainis ;
Bagdonas, Alfredas ;
Osores, Juan Lema ;
Tomkowski, Witold ;
Mot, Stefan ;
Panchenko, Elizaveta ;
Tan, Ru San ;
Gaspar, Ludovit ;
Jacobson, Barry ;
Monreal, Manuel ;
Ongen, Gul ;
Parkhomenko, Alexander ;
Uprichard, James ;
Yusen, Roger .
NEW ENGLAND JOURNAL OF MEDICINE, 2016, 375 (06) :534-544
[4]  
Dimakakos E, 2016, OPEN FORUM INFECT DI, V3
[5]   Cross Talk Pathways Between Coagulation and Inflammation [J].
Foley, Jonathan H. ;
Conway, Edward M. .
CIRCULATION RESEARCH, 2016, 118 (09) :1392-1408
[6]   Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China [J].
Huang, Chaolin ;
Wang, Yeming ;
Li, Xingwang ;
Ren, Lili ;
Zhao, Jianping ;
Hu, Yi ;
Zhang, Li ;
Fan, Guohui ;
Xu, Jiuyang ;
Gu, Xiaoying ;
Cheng, Zhenshun ;
Yu, Ting ;
Xia, Jiaan ;
Wei, Yuan ;
Wu, Wenjuan ;
Xie, Xuelei ;
Yin, Wen ;
Li, Hui ;
Liu, Min ;
Xiao, Yan ;
Gao, Hong ;
Guo, Li ;
Xie, Jungang ;
Wang, Guangfa ;
Jiang, Rongmeng ;
Gao, Zhancheng ;
Jin, Qi ;
Wang, Jianwei ;
Cao, Bin .
LANCET, 2020, 395 (10223) :497-506
[7]  
Klok FA, 2020, THROMB RES, V191, P145, DOI [10.1016/j.thromres.2020.04.041, 10.1016/j.thromres.2020.04.013]
[8]   The 2019 ESC Guidelines on the Diagnosis and Management of Acute Pulmonary Embolism [J].
Konstantinides, Stavros V. ;
Meyer, Guy .
EUROPEAN HEART JOURNAL, 2019, 40 (42) :3453-3455
[9]   Venous and arterial thromboembolic complications in COVID-19 patients admitted to an academic hospital in Milan, Italy [J].
Lodigiani, Corrado ;
Iapichino, Giacomo ;
Carenzo, Luca ;
Cecconi, Maurizio ;
Ferrazzi, Paola ;
Sebastian, Tim ;
Kucher, Nils ;
Studt, Jan-Dirk ;
Sacco, Clara ;
Alexia, Bertuzzi ;
Sandri, Maria Teresa ;
Barco, Stefano .
THROMBOSIS RESEARCH, 2020, 191 :9-14
[10]   Empirical systemic anticoagulation is associated with decreased venous thromboembolism in critically ill influenza A H1N1 acute respiratory distress syndrome patients [J].
Obi, Andrea T. ;
Tignanelli, Christopher J. ;
Jacobs, Benjamin N. ;
Arya, Shipra ;
Park, Pauline K. ;
Wakefield, Thomas W. ;
Henke, Peter K. ;
Napolitano, Lena M. .
JOURNAL OF VASCULAR SURGERY-VENOUS AND LYMPHATIC DISORDERS, 2019, 7 (03) :317-324