PLA micro- and nano-particles

被引：250
作者：
Lee, Byung Kook
Yun, Yeonhee
Park, Kinam [1 ,2 ]
机构：
[1] Purdue Univ, Dept Biomed Engn, 206 S Martin Jischke Dr, W Lafayette, IN 47907 USA
[2] Purdue Univ, Dept Pharmaceut, 206 S Martin Jischke Dr, W Lafayette, IN 47907 USA
来源：
ADVANCED DRUG DELIVERY REVIEWS | 2016年 / 107卷
关键词：
PIA; Micro-particles; Nano-particles; Fabrication methods; Drug delivery system; BIODEGRADABLE POLYMERIC NANOPARTICLES; PLGA-BASED NANOPARTICLES; HYDROGEL TEMPLATE METHOD; FORMING DRUG-DELIVERY; OF-THE-ART; IN-VITRO; CONTROLLED-RELEASE; SUSTAINED-RELEASE; POLY(LACTIC ACID); ANTICANCER DRUG;
D O I：
10.1016/j.addr.2016.05.020
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Poly(D,L-lactic acid) (PLA) has been widely used for various biomedical applications for its biodegradable, biocompatible, and nontoxic properties. Various methods, such as emulsion, salting out, and precipitation, have been used to make better PLA micro- and nano-particle formulations. They are widely used as controlled drug delivery systems of therapeutic molecules, including proteins, genes, vaccines, and anticancer drugs. Even though PLA-based particles have challenges to overcome, such as low drug loading capacity, low encapsulation efficiency, and terminal sterilization, continuous innovations in particulate formulations will lead to development of clinically useful formulations. (C) 2016 Elsevier B.V. All rights reserved.
引用
收藏
页码：176 / 191
页数：16
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