Argifin; efficient solid phase total synthesis and evalution of analogues of acyclic peptide

被引：15

作者：

Sunazuka, Toshiaki ^{[1
]}

Sugawara, Akihiro ^{[1
]}

Iguchi, Kanami ^{[1
]}

Hirose, Tomoyasu ^{[1
]}

Nagai, Kenichiro ^{[1
]}

Noguchi, Yoshihiko ^{[1
]}

Saito, Yoshifumi ^{[1
]}

Yamamoto, Tsuyoshi ^{[1
]}

Ui, Hideaki ^{[1
]}

Gouda, Hiroaki ^{[2
]}

Shiomi, Kazuro ^{[1
]}

Watanabe, Takeshi ^{[3
]}

Omura, Satoshi ^{[1
]}

机构：

[1] Kitasato Univ, Grad Sch Infect Control Sci, Kitasato Inst Life Sci, Minato Ku, Tokyo 1088641, Japan

[2] Kitasato Univ, Sch Pharmaceut Sci, Minato Ku, Tokyo 1088641, Japan

[3] Niigata Univ, Fac Agr, Dept Appl Biol Chem, Niigata 9502181, Japan

来源：

BIOORGANIC & MEDICINAL CHEMISTRY | 2009年 / 17卷 / 07期

关键词：

Argifin; Chitinase; Solid phase; Serratia marcescens; GLIOCLADIUM SP FTD-0668; CHITINASE INHIBITOR;

D O I：

10.1016/j.bmc.2009.02.047

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

An effective solid phase synthesis of Argifin, providing subsequent access to effective synthesis of analogues, was developed in 13% overall yield, as well as elucidating structure-activity relationships. The novel acyclic peptide 18b, prepared from a synthetic intermediate of Argifin, was found to be 70 times more potent as an inhibitor of Serratia marcescens chitinases B than Argifin itself (c) 2009 Elsevier Ltd. All rights reserved.

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收藏

页码：2751 / 2758

页数：8

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