Quantum-Dot-Based Aptamer Beacons for K+ Detection

被引：7
作者：
Wu, Tsai-Chin [1 ]
Zhao, Guijun [2 ]
Lu, Hui [1 ]
Dutta, Mitra [3 ,4 ]
Stroscio, Michael A. [1 ,3 ,4 ]
机构：
[1] Univ Illinois, Dept Bioengn, Chicago, IL 60607 USA
[2] Shanghai Jiao Tong Univ, Sch Med, Shanghai Childrens Hosp, Shanghai Inst Med Genet, Shanghai 200052, Peoples R China
[3] Univ Illinois, Dept Elect & Comp Engn, Chicago, IL 60607 USA
[4] Univ Illinois, Dept Phys, Chicago, IL 60607 USA
来源：
IEEE SENSORS JOURNAL | 2013年 / 13卷 / 05期
关键词：
Aptamer; deoxyribonucleic acid; molecular beacon; nanotechnology; potassium ion; quantum dot; tetraplex; thrombin-binding aptamer; THROMBIN-BINDING APTAMER; RESONANCE ENERGY-TRANSFER; G-QUADRUPLEX; DNA;
D O I：
10.1109/JSEN.2012.2229387
中图分类号：
TM [电工技术]; TN [电子技术、通信技术];
学科分类号：
0808 ; 0809 ;
摘要：
Herein, aptamer-based quantum-dot detectors of K+ made of two-different K+ aptamers are compared. These deoxyribonucleic acid-based aptamers are TBA (5' GGT TGG TGT GGT TGG 3') and AG3 (5' GGG TTA GGG TTA GGG TTA GGG 3'). The nanoscale aptamer-quantum-dot-based detectors described in this paper are synthesized and tested in DI water aliquots that contain KCl. The results including data suggest that beacons made of AG3 and TBA serve better as an ion indicator in different potassium level regions. As a result, aptamer beacon made of AG3 has better potential in the design of take-home diagnostic devices for hyperkalemia and hypokalemia.
引用
收藏
页码：1549 / 1553
页数：5
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