Immunomodulation of the tumor microenvironment by Toll-like receptor-3 (TLR3) ligands

被引：24

作者：

Chew, Valerie ^{[1
]}

Abastado, Jean-Pierre ^{[1
]}

机构：

[1] ASTAR, Singapore Immunol Network SIgN, Biomed Grove 8A, Singapore, Singapore

来源：

ONCOIMMUNOLOGY | 2013年 / 2卷 / 04期

关键词：

cancer vaccine; chemokine; hepatocellular carcinoma; immunotherapy; Toll-like receptor; tumor microenvironment; HEPATOCELLULAR-CARCINOMA; INFILTRATION; RECRUITMENT; EXPRESSION; MELANOMA; CELLS;

D O I：

10.4161/onci.23493

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

In hepatocellular carcinoma (HCC) patients, the intratumoral expression of Toll-like receptor-3 (TLR3) correlates with prolonged survival. We demonstrated that TLR3 ligands can operate through three independent mechanisms: by directly killing TLR3-expressing cancer cells, by inducing T- and natural killer (NK)-cell infiltration and by activating TLR3-expressing NK cells.

引用

页数：3

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