Advances in Supercritical Fluid Chromatography for the Analysis of Chiral and Achiral Pharmaceuticals

被引:0
作者
De Klerck, Katrijn [1 ]
Mangelings, Debby [1 ]
Vander Heyden, Yvan [1 ]
机构
[1] Vrije Univ Brussel, Pharmaceut Res Ctr, Dept Analyt Chem & Pharmaceut Technol, Brussels, Belgium
关键词
LIQUID-CHROMATOGRAPHY; STATIONARY PHASES; COLUMN; SEPARATIONS; PARTICLES; SILICA; ENANTIOSEPARATIONS; PERFORMANCE; ENVIRONMENT; MOLECULES;
D O I
暂无
中图分类号
O65 [分析化学];
学科分类号
070302 ; 081704 ;
摘要
A revival of supercritical fluid chromatography (SFC) has been observed recently. SFC has repeatedly enabled fast and efficient separations, and in some cases has even outperformed high performance liquid chromatography (HPLC). This article provides an overview of the most recent advances in the field of chiral and achiral separations in SFC. This involves research focused on the most critical parameters in SFC separations, but also on practical issues such as the serial coupling of columns. The recent evolution from classic SFC to ultrahigh-performance supercritical fluid chromatography (UPSFC) is also discussed.
引用
收藏
页码:24 / +
页数:6
相关论文
共 24 条
[1]   Supercritical fluid chromatography tandem-column method development in pharmaceutical sciences for a mixture of four stereoisomers [J].
Barnhart, WW ;
Gahm, KH ;
Thomas, S ;
Notari, S ;
Semin, D ;
Cheetham, J .
JOURNAL OF SEPARATION SCIENCE, 2005, 28 (07) :619-626
[2]  
BARTLE K D, 1988, P1
[3]   Characterization of a 2.6 μm Kinetex porous shell hydrophilic interaction liquid chromatography column in supercritical fluid chromatography with a comparison to 3 μm totally porous silica [J].
Berger, Terry A. .
JOURNAL OF CHROMATOGRAPHY A, 2011, 1218 (28) :4559-4568
[4]   Demonstration of High Speeds with Low Pressure Drops Using 1.8 μm Particles in SFC [J].
Berger, Terry A. .
CHROMATOGRAPHIA, 2010, 72 (7-8) :597-602
[5]   Development of a supercritical fluid chromatography high-resolution separation method suitable for pharmaceuticals using cyanopropyl silica [J].
Brunelli, Claudio ;
Zhao, Yining ;
Brown, Melissa-Hanna ;
Sandra, Pat .
JOURNAL OF CHROMATOGRAPHY A, 2008, 1185 (02) :263-272
[6]   Supercritical fluid chromatography for the enantioseparation of pharmaceuticals [J].
De Klerck, Katrijn ;
Mangelings, Debby ;
Vander Heyden, Yvan .
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2012, 69 :77-92
[7]   Combined use of isopropylamine and trifluoroacetic acid in methanol-containing mobile phases for chiral supercritical fluid chromatography [J].
De Klerck, Katrijn ;
Mangelings, Debby ;
Clicq, David ;
De Boever, Filip ;
Vander Heyden, Yvan .
JOURNAL OF CHROMATOGRAPHY A, 2012, 1234 :72-79
[8]   Supercritical fluid chromatography in research laboratories: Design, development and implementation of an efficient generic screening for exploiting this technique in the achiral environment [J].
de la Puente, M. L. ;
Lopez Soto-Yarritu, P. ;
Burnett, J. .
JOURNAL OF CHROMATOGRAPHY A, 2011, 1218 (47) :8551-8560
[9]   Comparative performance of capillary columns made with totally porous and core-shell particles coated with a polysaccharide-based chiral selector in nano-liquid chromatography and capillary electrochromatography [J].
Fanali, Salvatore ;
D'Orazio, Giovanni ;
Farkas, Tivadar ;
Chankvetadze, Bezhan .
JOURNAL OF CHROMATOGRAPHY A, 2012, 1269 :136-142
[10]  
Grand-Guillaume Perrenoud A., 2012, J CHROMATOGR A, V1266, P158