Electrooxidative Amination of sp2 C-H Bonds: Coupling of Amines with Aryl Amides via Copper Catalysis

被引：57

作者：

Kathiravan, Subban ^{[1
,2
]}

Suriyanarayanan, Subramanian ^{[1
,2
]}

Nicholls, Ian A. ^{[1
,2
]}

机构：

[1] Linnaeus Univ, Dept Chem & Biomed Sci, Bioorgan & Biophys Chem Lab, SE-39182 Kalmar, Sweden

[2] Linnaeus Univ, Ctr Biomat Chem, SE-39182 Kalmar, Sweden

来源：

ORGANIC LETTERS | 2019年 / 21卷 / 07期

基金：

瑞典研究理事会;

关键词：

ORGANIC ELECTROSYNTHESIS; AMIDATION; HALIDES; ARENES; FUNCTIONALIZATION; COMPATIBILITY; OXYGENATION; ALKYLAMINES; ACTIVATION; BENZAMIDES;

D O I：

10.1021/acs.orglett.9b00003

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Metal-catalyzed cross-coupling reactions are among the most important transformations in organic synthesis. However, the use of C-H activation for sp(2) C-N bond formation remains one of the major challenges in the field of cross-coupling chemistry. Described herein is the first example of the synergistic combination of copper catalysis and electrocatalysis for aryl C-H amination under mild reaction conditions in an atom-and step-economical manner with the liberation of H-2 as the sole and benign byproduct.

引用

页码：1968 / 1972

页数：5

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