Ibuprofen-loaded hydrophilic biocompatible polymeric (Eudragit L100) nanoparticles were formulated for the taste masking and solubility enhancement using the spray-drying technique. The various batches of ibuprofen-loaded nanoparticles were prepared by varying the mass ratios of methacrylate copolymer (Eudragit L100), PVP K30, and beta-cyclodextrin. The different characteristics of the recovered nanoparticles were evaluated by field emission scanning electron microscopy (FESEM), particle size analysis, X-ray diffraction (XRD), and Fourier transform infrared spectroscopy (FTIR) as well as taste-masking ability and phase solubility. The nanoparticles prepared using the mixture showed a decrease in crystallinity, narrow particle size distribution, and increased solubility as compared to those prepared using pure ibuprofen under similar operating conditions. FESEM results revealed that the nanoparticles are smooth, spherical, and of nearly uniform size. The taste evaluations of the encapsulated nanoparticles were carried out using an in vitro method by measuring the drug release rate.
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Apollonia Univ Iasi, Fac Med Dent, Dept Biomat, Pacurari St 11, Iasi 700511, RomaniaApollonia Univ Iasi, Fac Med Dent, Dept Biomat, Pacurari St 11, Iasi 700511, Romania
Daraba, Oana Maria
Cadinoiu, Anca Niculina
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Apollonia Univ Iasi, Fac Med Dent, Dept Biomat, Pacurari St 11, Iasi 700511, RomaniaApollonia Univ Iasi, Fac Med Dent, Dept Biomat, Pacurari St 11, Iasi 700511, Romania
Cadinoiu, Anca Niculina
Rata, Delia Mihaela
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Apollonia Univ Iasi, Fac Med Dent, Dept Biomat, Pacurari St 11, Iasi 700511, RomaniaApollonia Univ Iasi, Fac Med Dent, Dept Biomat, Pacurari St 11, Iasi 700511, Romania
Rata, Delia Mihaela
Atanase, Leonard Ionut
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Apollonia Univ Iasi, Fac Med Dent, Dept Biomat, Pacurari St 11, Iasi 700511, RomaniaApollonia Univ Iasi, Fac Med Dent, Dept Biomat, Pacurari St 11, Iasi 700511, Romania
Atanase, Leonard Ionut
Vochita, Gabriela
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NIRDBS Inst Biol Res Iasi, Dept Expt & Appl Biol, Lascar Catargi 47, Iasi 700107, RomaniaApollonia Univ Iasi, Fac Med Dent, Dept Biomat, Pacurari St 11, Iasi 700511, Romania
机构:
Gazi Univ, Dept Adv Technol, Ankara, Turkey
Gazi Univ, Tech Sci Vocat Sch, Dept Mat & Mat Proc Technol, Ankara, TurkeyGazi Univ, Dept Adv Technol, Ankara, Turkey
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University Institute of Chemical Technology, North Maharashtra University, Jalgaon, Maharashtra,425 001, IndiaUniversity Institute of Chemical Technology, North Maharashtra University, Jalgaon, Maharashtra,425 001, India