Development and Evaluation of Ibuprofen Loaded Hydrophilic Biocompatible Polymeric Nanoparticles for the Taste Masking and Solubility Enhancement

Ibuprofen-loaded hydrophilic biocompatible polymeric (Eudragit L100) nanoparticles were formulated for the taste masking and solubility enhancement using the spray-drying technique. The various batches of ibuprofen-loaded nanoparticles were prepared by varying the mass ratios of methacrylate copolymer (Eudragit L100), PVP K30, and beta-cyclodextrin. The different characteristics of the recovered nanoparticles were evaluated by field emission scanning electron microscopy (FESEM), particle size analysis, X-ray diffraction (XRD), and Fourier transform infrared spectroscopy (FTIR) as well as taste-masking ability and phase solubility. The nanoparticles prepared using the mixture showed a decrease in crystallinity, narrow particle size distribution, and increased solubility as compared to those prepared using pure ibuprofen under similar operating conditions. FESEM results revealed that the nanoparticles are smooth, spherical, and of nearly uniform size. The taste evaluations of the encapsulated nanoparticles were carried out using an in vitro method by measuring the drug release rate.