Positron emission tomography radiotracers for imaging hypoxia

被引：20

作者：

Wuest, Melinda ^{[1
]}

Wuest, Frank ^{[1
]}

机构：

[1] Univ Alberta, Dept Oncol, Edmonton, AB T6G 1Z2, Canada

来源：

JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS | 2013年 / 56卷 / 3-4期

关键词：

tumor hypoxia; radiotracers; fluorine-18; radiochemistry; TUMOR HYPOXIA; PROGNOSTIC VALUE; IN-VITRO; F-18; PET; MARKER; TISSUE; 2-NITROIMIDAZOLE; BIODISTRIBUTION; RADIOSYNTHESIS;

D O I：

10.1002/jlcr.2997

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Localized hypoxia, the physiological hallmark of many clinical pathologies, is the consequence of acute or chronic ischemia in the affected region or tissue. The versatility, sensitivity, quantitative nature, and increasing availability of positron emission tomography (PET) make it the preclinical and clinical method of choice for functional imaging of tissue hypoxia at the molecular level. The progress and current status of radiotracers for hypoxia-specific PET imaging are reviewed in this article including references mainly focused on radiochemistry and also relevant to molecular imaging of hypoxia in preclinical and clinical studies.

引用

页码：244 / 250

页数：7

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