Positron emission tomography radiotracers for imaging hypoxia

被引：20
|
作者：
Wuest, Melinda [1 ]
Wuest, Frank [1 ]
机构：
[1] Univ Alberta, Dept Oncol, Edmonton, AB T6G 1Z2, Canada
来源：
JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS | 2013年 / 56卷 / 3-4期
关键词：
tumor hypoxia; radiotracers; fluorine-18; radiochemistry; TUMOR HYPOXIA; PROGNOSTIC VALUE; IN-VITRO; F-18; PET; MARKER; TISSUE; 2-NITROIMIDAZOLE; BIODISTRIBUTION; RADIOSYNTHESIS;
D O I：
10.1002/jlcr.2997
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
Localized hypoxia, the physiological hallmark of many clinical pathologies, is the consequence of acute or chronic ischemia in the affected region or tissue. The versatility, sensitivity, quantitative nature, and increasing availability of positron emission tomography (PET) make it the preclinical and clinical method of choice for functional imaging of tissue hypoxia at the molecular level. The progress and current status of radiotracers for hypoxia-specific PET imaging are reviewed in this article including references mainly focused on radiochemistry and also relevant to molecular imaging of hypoxia in preclinical and clinical studies.
引用
收藏
页码：244 / 250
页数：7
相关论文
共 50 条
  • [1] Radiotracers for positron emission tomography imaging
    Gillings, Nic
    MAGNETIC RESONANCE MATERIALS IN PHYSICS BIOLOGY AND MEDICINE, 2013, 26 (01): : 149 - 158
  • [2] Radiotracers for positron emission tomography imaging
    Nic Gillings
    Magnetic Resonance Materials in Physics, Biology and Medicine, 2013, 26 : 149 - 158
  • [3] Positron Emission Tomography Imaging of Tumor Hypoxia
    Fang, Shengwei
    Hong, Mei Tian
    Zhang, Hong
    CURRENT MEDICAL IMAGING, 2010, 6 (01) : 8 - 16
  • [4] Positron emission tomography (PET) radiotracers for prostate cancer imaging
    Walker, Stephanie M.
    Lim, Ilhan
    Lindenberg, Liza
    Mena, Esther
    Choyke, Peter L.
    Turkbey, Baris
    ABDOMINAL RADIOLOGY, 2020, 45 (07) : 2165 - 2175
  • [5] Recent Advances in Positron Emission Tomography (PET) Radiotracers for Imaging Phosphodiesterases
    Ignacio Andres, Jose
    De Angelis, Meri
    Alcazar, Jesus
    Celen, Sofie
    Bormans, Guy
    CURRENT TOPICS IN MEDICINAL CHEMISTRY, 2012, 12 (11) : 1224 - 1236
  • [6] Antibiotic-Derived Radiotracers for Positron Emission Tomography: Nuclear or "Unclear" Infection Imaging?
    Gouws, Arno Christiaan
    Kruger, Hendrik Gerhardus
    Gheysens, Olivier
    Zeevaart, Jan Rijn
    Govender, Thavendran
    Naicker, Tricia
    Ebenhan, Thomas
    ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2022, 61 (45)
  • [7] Hypoxia positron emission tomography imaging: combining information on perfusion and tracer retention to improve hypoxia specificity
    Busk, Morten
    Munk, Ole L.
    Jakobsen, Steen S.
    Horsman, Michael R.
    ACTA ONCOLOGICA, 2017, 56 (11) : 1583 - 1590
  • [8] Positron emission tomography (PET) imaging with F-18-based radiotracers
    Alauddin, Mian M.
    AMERICAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, 2012, 2 (01): : 55 - 76
  • [9] In Vivo Ester Hydrolysis as a New Approach in Development of Positron Emission Tomography Tracers for Imaging Hypoxia
    Zhang, Lifang
    Yao, Xinyue
    Cao, Jianhua
    Hong, Haiyan
    Zhang, Aili
    Zhao, Ruiyue
    Zhang, Yan
    Zha, Zhihao
    Liu, Yajing
    Qiao, Jinping
    Zhu, Lin
    Kung, Hank F.
    MOLECULAR PHARMACEUTICS, 2019, 16 (03) : 1156 - 1166
  • [10] Review of Positron Emission Tomography Tracers for Imaging of Tumor Hypoxia
    Imam, Seyed K.
    CANCER BIOTHERAPY AND RADIOPHARMACEUTICALS, 2010, 25 (03) : 365 - 374
12345