Testicular tumors in 190 dogs: clinical, macroscopic and histopathological aspects

被引:0
作者
Nascimento, Harlan H. L. [1 ]
Santos, Alex dos [1 ]
Prante, Amanda L. [2 ]
Lamego, Eryca C. [2 ]
Tondo, Luis A. S. [2 ]
Flores, Mariana M. [3 ]
Fighera, Rafael A. [3 ]
Kommers, Glaucia D. [3 ]
机构
[1] Univ Fed Santa Maria UFSM, Ctr Ciencia Rurais CCR, Grad Program Vet Med Emphasis Pathol & Vet Clin P, Av Roraima 1000, BR-97105900 Santa Maria, RS, Brazil
[2] Univ Fed Santa Maria UFSM, Ctr Ciencia Rurais CCR, Curso Med Vet, Av Roraima 1000, BR-97105900 Santa Maria, RS, Brazil
[3] Univ Fed Santa Maria UFSM, Ctr Ciencias Saude, Dept Patol, Lab Patol Vet, Av Roraima 1000, BR-97105900 Santa Maria, RS, Brazil
来源
PESQUISA VETERINARIA BRASILEIRA | 2020年 / 40卷 / 07期
关键词
Testicular tumors; dogs; clinics; macroscopy; histopathology; testicular neoplasms; clinical aspects; morphology; LEYDIG-CELL TUMOR; SPERMATOCYTIC SEMINOMA; STROMAL TUMORS; NEOPLASMS; ESTROGEN; PROSTATE; TESTES;
D O I
10.1590/1678-5150-PVB-6615
中图分类号
S85 [动物医学(兽医学)];
学科分类号
0906 ;
摘要
This study aimed to characterize the prevalence and clinical, macroscopic and histopathological aspects of dogs affected by testicular tumors based on biopsy specimens from the Laboratorio de Patologia Veterinciria of the Universidade Federal de Santa Maria (LPV-UFSM) over 19 years. Parameters regarding the age, size, and breed of the affected dogs were also established. Of all dogs with some type of neoplasm submitted to histopathological analysis at the LPV over these 19 years (n=1,900), 213 (11.2%) had at least one testicular neoplasm. The tissues of 190 dogs (with 220 neoplasms) were available for histological reassessment. The dogs in this study had different types of testicular tumors with relatively similar frequencies. In descending order, the most frequent testicular neoplasms were seminomas (88/220), Leydig (interstitial) cell tumor (LCT; 64/220), Sertoli cell tumor (SCT; 61/220), and mixed germ cell-sex cord stromal tumor (MGSCT) (07/220). Among the dogs of defined breed (119 cases), large breeds had the largest number of cases (50/119), followed by small (47/119) and medium-sized (22/119) breeds. The ages of dogs affected by testicular tumors ranged from 10 months to 18 years. Increased testicular volume was the most common clinical manifestation. Eleven dogs presented information about clinical signs suggestive of hyperestrogenism syndrome (feminization). In seminomas, the diffuse pattern predominated over the intratubular pattern. Two sites (luminal and basal compartments) suggestive of the onset of neoplastic transformations in germ cells were observed in intratubular seminomas. They corroborate the hypothesis that canine seminomas possibly have pathogenesis similar to that observed in human spermatocytic seminomas. The SCTs and LCTs presented high cell morphology variation. SCTs had neoplastic cells organized in five different histological arrangements. As for LCT, solid-diffuse and cystic-vascular histological patterns were the most commonly observed. Through this study, it was possible to establish some of the leading clinical, macroscopic, and histopathological aspects of testicular neoplasms diagnosed over 19 years in the area covered by the LPV-UFSM.
引用
收藏
页码:525 / 535
页数:11
相关论文
共 43 条
[1]  
Agnew D. W., 2017, Tumors in domestic animals, P689
[2]  
Argenta FF, 2016, ACTA SCI VET, V44
[3]  
Bahrami A, 2007, ARCH PATHOL LAB MED, V131, P1267
[4]   Immunohistochemical Study of Mixed Germ Cell Sex Cord Stromal Tumours in 13 Canine Testes [J].
Banco, B. ;
Giudice, C. ;
Ghisleni, G. ;
Romussi, S. ;
Behar, D. K. ;
Grieco, V. .
JOURNAL OF COMPARATIVE PATHOLOGY, 2015, 152 (2-3) :182-187
[5]   Testicular germ-cell cancer [J].
Bosl, GJ ;
Motzer, RJ .
NEW ENGLAND JOURNAL OF MEDICINE, 1997, 337 (04) :242-253
[6]   Testicular germ cell tumours in dogs are predominantly of spermatocytic seminoma type and are frequently associated with somatic cell tumours [J].
Bush, J. M. ;
Gardiner, D. W. ;
Palmer, J. S. ;
Meyts, E. Rajpert-De ;
Veeramachaneni, D. N. R. .
INTERNATIONAL JOURNAL OF ANDROLOGY, 2011, 34 (04) :E288-E295
[7]   Multiple Cutaneous Metastasis of a Malignant Leydig Cell Tumour in a Dog [J].
Canadas, A. ;
Romao, P. ;
Gartner, F. .
JOURNAL OF COMPARATIVE PATHOLOGY, 2016, 155 (2-3) :181-184
[8]  
COTCHIN E., 1960, JOUR COMP PATHOL AND THERAP, V70, P232, DOI 10.1016/S0368-1742(60)80024-0
[9]   Testicular Interstitial Cell Tumor with Disseminated Cutaneous Metastasis in a Dog [J].
de Lima Nascimento, Harlan Hallamys ;
Tochetto, Camila ;
Lucena, Ricardo Barbosa ;
Kommers, Glaucia Denise .
ACTA SCIENTIAE VETERINARIAE, 2019, 47
[10]   TESTICULAR TUMOURS IN DOG [J].
DOW, C .
JOURNAL OF COMPARATIVE PATHOLOGY AND THERAPEUTICS, 1962, 72 (03) :247-&