Green methodologies in organic synthesis: recent developments in our laboratories

被引：30

作者：

Hafez, Ebtesam Abdul Aziz ^{[1
]}

Al-Mousawi, Saleh Mohammed ^{[2
]}

Moustafa, Moustafa Sherief ^{[2
]}

Sadek, Kmal Usef ^{[3
]}

Elnagdi, Mohamed Hilmy ^{[2
]}

机构：

[1] Cairo Univ, Dept Chem, Fac Sci, Giza, Egypt

[2] Kuwait Univ, Fac Sci, Dept Chem, Safat, Kuwait

[3] Menia Univ, Dept Chem, Fac Sci, Al Minya, Egypt

来源：

GREEN CHEMISTRY LETTERS AND REVIEWS | 2013年 / 6卷 / 03期

关键词：

green methodologies; synthesis; SOLAR THERMOCHEMICAL REACTIONS; IV AMMONIUM-NITRATE; ONE-POT SYNTHESIS; HETEROCYCLIC SYNTHESIS; ACTIVATED NITRILES; DERIVATIVES; CHEMISTRY; ENAMINES; AMINES; 3,4-DIHYDROPYRIMIDIN-2(1H)-ONES;

D O I：

10.1080/17518253.2012.740078

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The results of the studies carried out in our laboratories during the last 15 years, aimed at developing green methodologies for the synthesis of polyfunctionalized heteroaromatic substances, are surveyed. The results of the investigations demonstrate that green methodologies are not only less hazard than classical preparative methods but they also are more efficient and economical. For example, short reaction times and higher yields are observed for reactions in which conventional heating is replaced by microwave or ultrasound irradiation. The implementation of multicomponent reactions in green preparative routes also reduces the cost of carrying out the reactions because multiple separation and crystallization steps are avoided. In general, by employing the new green methodologies we have been able to produce a large number of polyfunctional aromatic substances in a highly efficient manner.

引用

页码：189 / 210

页数：22

共 87 条

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