Design, synthesis and screening of some novel benzoxazole based 1,3,4-oxadiazoles as potential antimicrobial agents

被引：11

作者：

Vodela, Sunil ^{[1
]}

Mekala, Raghu Vardhan Reddy ^{[2
]}

Danda, Ravinder Reddy ^{[3
]}

Kodhati, Venkateshwarlu ^{[4
]}

机构：

[1] Tana Padmavathi Coll Engn, Kazipet 506003, Andhra Pradesh, India

[2] Kakatiya Univ, Dept Chem, Warangal 506009, Andhra Pradesh, India

[3] Mahathma Gandhi Univ, Dept Chem, Nalgonda 508254, Andhra Pradesh, India

[4] Vaagdevi Coll Pharm, Hanamkonda 506001, Andhra Pradesh, India

来源：

CHINESE CHEMICAL LETTERS | 2013年 / 24卷 / 07期

关键词：

Benzoxazoles; 1,3,4-Oxadiazoles; Antimicrobial activity; DERIVATIVES;

D O I：

10.1016/j.cclet.2013.04.005

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A series of novel 2-(5-substituted-[1,3,4]oxadiazol-2-yl)-benzoxazoles (7a-h) were synthesized in good yields in two different directions by involving benzoxazole-2-carboxylic acid (1) as raw material and benzoxazole-2-carbonyl chloride (2), benzoxazole-2-carboxylic acid methyl ester (3), benzoxazole-2-carboxylic acid hydrazide (4), benzoxazole-2-carboxylic acid N'-acetyl hydrazide (5a-d) and benzoxazole-2-carboxylic acid-ethylidene-hydrazides (6a-d) as reactive intermediates. The chemical structures of all the synthesized compounds were elucidated by their IR, H-1 NMR and C-13 NMR and mass spectral data. Further, the target compounds were screened for their antimicrobial activity against various Gram-positive and Gram-negative bacteria. (C) 2013 Raghu Vardhan Reddy Mekala. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.

引用

页码：625 / 628

页数：4

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