Primary open angle glaucoma;
rs1533428;
rs12994401;
Chromosome;
2p;
COMMON VARIANTS;
RISK;
ASSOCIATION;
PREVALENCE;
FAMILY;
GENE;
POAG;
D O I:
10.3109/13816810.2012.736592
中图分类号:
Q3 [遗传学];
学科分类号:
071007 ;
090102 ;
摘要:
Purpose: Genetic factors have been shown to play a remarkable role in the pathophysiology of glaucoma. Recently, two polymorphisms (rs1533428 and rs12994401) on chromosome 2p were found to be strongly associated with POAG in an Afro-Caribbean population in Barbados, West Indies. As data with regard to the role of these polymorphisms in a Caucasian population are lacking, the present study was set to investigate a hypothetical association between these polymorphisms and POAG in a Caucasian population. Methods: In total 723 participants were included in this study comprising 366 patients with POAG and 357 control subjects from the southern part of Austria. Genotyping of rs1533428 and rs12994401 was performed using polymerase chain reaction. Results: Allelic frequencies and genotype distributions of rs1533428 and rs12994401 did not show statistical significance between patients with POAG and control subjects (p < 0.05). Presence of the rs1533428 T-allele was associated with an odds ratio of 0.95 (95% CI: 0.76-1.19; p = 0.69) for POAG, while the rs12994401 T-allele was associated with an odds ratio of 0.94 (95% CI: 0.73-1.21; p = 0.65) for POAG. Conclusion: Our data suggest that rs1533428 and rs12994401 themselves are unlikely major risk factors for POAG in a Central European population.
机构:
Department of Ophthalmology and Visual Rehabilitation, University Hospital WAM, Central Hospital in Lodz, Medical University of LodzDepartment of Ophthalmology and Visual Rehabilitation, University Hospital WAM, Central Hospital in Lodz, Medical University of Lodz
Halina Olszewska
Joanna Kosny
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机构:
Department of Ophthalmology and Visual Rehabilitation, University Hospital WAM, Central Hospital in Lodz, Medical University of LodzDepartment of Ophthalmology and Visual Rehabilitation, University Hospital WAM, Central Hospital in Lodz, Medical University of Lodz
Joanna Kosny
Piotr Jurowski
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机构:
Department of Ophthalmology and Visual Rehabilitation, University Hospital WAM, Central Hospital in Lodz, Medical University of LodzDepartment of Ophthalmology and Visual Rehabilitation, University Hospital WAM, Central Hospital in Lodz, Medical University of Lodz
Piotr Jurowski
Anna Jegier
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机构:
Department of Sports Medicine, Medical University of LodzDepartment of Ophthalmology and Visual Rehabilitation, University Hospital WAM, Central Hospital in Lodz, Medical University of Lodz
机构:
King Saud Univ, Dept Ophthalmol, Glaucoma Res Chair, Coll Med, POB 245, Riyadh 11411, Saudi ArabiaKing Saud Univ, Dept Ophthalmol, Glaucoma Res Chair, Coll Med, POB 245, Riyadh 11411, Saudi Arabia
Kondkar, Altaf A.
Azad, Taif A.
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机构:
King Saud Univ, Dept Ophthalmol, Glaucoma Res Chair, Coll Med, POB 245, Riyadh 11411, Saudi ArabiaKing Saud Univ, Dept Ophthalmol, Glaucoma Res Chair, Coll Med, POB 245, Riyadh 11411, Saudi Arabia
Azad, Taif A.
Almobarak, Faisal A.
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机构:
King Saud Univ, Dept Ophthalmol, Glaucoma Res Chair, Coll Med, POB 245, Riyadh 11411, Saudi ArabiaKing Saud Univ, Dept Ophthalmol, Glaucoma Res Chair, Coll Med, POB 245, Riyadh 11411, Saudi Arabia
Almobarak, Faisal A.
Abu-Amero, Khaled K.
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机构:
King Saud Univ, Dept Ophthalmol, Glaucoma Res Chair, Coll Med, POB 245, Riyadh 11411, Saudi ArabiaKing Saud Univ, Dept Ophthalmol, Glaucoma Res Chair, Coll Med, POB 245, Riyadh 11411, Saudi Arabia
Abu-Amero, Khaled K.
Al-Obeidan, Saleh A.
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机构:
King Saud Univ, Dept Ophthalmol, Glaucoma Res Chair, Coll Med, POB 245, Riyadh 11411, Saudi ArabiaKing Saud Univ, Dept Ophthalmol, Glaucoma Res Chair, Coll Med, POB 245, Riyadh 11411, Saudi Arabia