KTCNlncDB-a first platform to investigate lncRNAs expressed in human keratoconus and non-keratoconus corneas

被引：14

作者：

Szczesniak, Michal W. ^{[1
,2
]}

Kabza, Michal ^{[1
,2
]}

Karolak, Justyna A. ^{[1
,3
]}

Rydzanicz, Malgorzata ^{[4
]}

Nowak, Dorota M. ^{[1
,3
]}

Ginter-Matuszewska, Barbara ^{[1
,3
]}

Polakowski, Piotr ^{[5
]}

Ploski, Rafal ^{[4
]}

Szaflik, Jacek P. ^{[5
]}

Gajecka, Marzena ^{[1
,3
]}

机构：

[1] Poznan Univ Med Sci, Dept Genet & Pharmaceut Microbiol, Poznan, Poland

[2] Adam Mickiewicz Univ, Inst Antropol, Dept Integrat Genom, Poznan, Poland

[3] Polish Acad Sci, Inst Human Genet, Poznan, Poland

[4] Med Univ Warsaw, Dept Med Genet, Warsaw, Poland

[5] Med Univ Warsaw, Dept Ophthalmol, Warsaw, Poland

来源：

DATABASE-THE JOURNAL OF BIOLOGICAL DATABASES AND CURATION | 2017年

关键词：

GENE-EXPRESSION; RNA; RECONSTRUCTION; TRANSCRIPTOME; DATABASE; BETA;

D O I：

10.1093/database/baw168

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Keratoconus (KTCN, OMIM 148300) is a degenerative eye disorder characterized by progressive stromal thinning that leads to a conical shape of the cornea, resulting in optical aberrations and even loss of visual function. The biochemical background of the disease is poorly understood, which motivated us to perform RNA-Seq experiment, aimed at better characterizing the KTCN transcriptome and identification of long non-coding RNAs (lncRNAs) that might be involved in KTCN etiology. The in silico functional studies based on predicted lncRNA: RNA base-pairings led us to recognition of a number of lncRNAs possibly regulating genes with known or plausible links to KTCN. The lncRNA sequences and data regarding their predicted functions in controlling the RNA processing and stability are available for browse, search and download in KTCNlncDB (http://rhesus.amu.edu.pl/KTCNlncDB/), the first online platform devoted to KTCN transcriptome.

引用

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