Noninvasive acoustic manipulation of objects in a living body

被引：106

作者：

Ghanem, Mohamed A. ^{[1
]}

Maxwell, Adam D. ^{[1
,2
]}

Wang, Yak-Nam ^{[1
]}

Cunitz, Bryan W. ^{[1
]}

Khokhlova, Vera A. ^{[1
,3
]}

Sapozhnikov, Oleg A. ^{[1
,3
]}

Bailey, Michael R. ^{[1
,2
]}

机构：

[1] Univ Washington, Appl Phys Lab, Ctr Ind & Med Ultrasound, Seattle, WA 98105 USA

[2] Univ Washington, Sch Med, Dept Urol, Seattle, WA 98195 USA

[3] Moscow MV Lomonosov State Univ, Phys Fac, Moscow 119991, Russia

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 2020年 / 117卷 / 29期

基金：

美国国家卫生研究院; 俄罗斯基础研究基金会;

关键词：

acoustic tweezers; acoustic radiation force; kidney stones; RADIATION FORCE; TIME-REVERSAL; ELASTIC SPHERE; BESSEL BEAM; PARTICLES; CELLS;

D O I：

10.1073/pnas.2001779117

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

In certain medical applications, transmitting an ultrasound beam through the skin to manipulate a solid object within the human body would be beneficial. Such applications include, for example, controlling an ingestible camera or expelling a kidney stone. In this paper, ultrasound beams of specific shapes were designed by numerical modeling and produced using a phased array. These beams were shown to levitate and electronically steer solid objects (3-mm-diameter glass spheres), along preprogrammed paths, in a water bath, and in the urinary bladders of live pigs. Deviation from the intended path was on average <10%. No injury was found on the bladder wall or intervening tissue.

引用

页码：16848 / 16855

页数：8

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