Low-dose combination of losartan, hydrochlorothiazide, and magnetic laser therapy: clinical effectiveness and quality of life impact

Aim. To study losartan effects, as monotherapy and in combination with hydrochlorothiazide (HCH) and magnetic laser therapy (MLT), on 24-hour blood pressure (BPM) and quality of life (QoL) parameters in patients with mild to moderate arterial hypertension (AH). Material and methods. Eighty-three men with mild to moderate AH were examined (mean age 51,4 5,6 years). At baseline and after 4 weeks of the treatment, 24-hour BPM and QoL parameters were measured in all participants. Results. After 4 weeks of the treatment, improved BP circadian rhythm (CR) was observed in all participants, especially in combined therapy groups. In the group of losartan, HCH and M LT, second 24-hour BPM demonstrated normalized BP CR, decreased prevalence of night CR type (from 39% to 25%), and reduced morning BP surge. Losartan monotherapy, despite its good antihypertensive effect, did not result in BP CR normalization. Synergistic impact of combined pharmaceutical therapy and M LT was observed in regard to antihypertensive effect and treatment tolerability. Maximal changes in various QoL domains were registered among patients with initially low scores (73%); among participants with initially high scores (27%), QoL did not change significantly. Conclusion. Losartan combination with HCH and M LT was effective in AH patients, demonstrating not only good antihypertensive effect, but also QoL improvement.