Prevalence, incidence rates and persistence of contact allergy and allergic contact dermatitis in The Odense Adolescence Cohort Study: a 15-year follow-up

被引:35
作者
Mortz, C. G. [1 ,2 ]
Bindslev-Jensen, C. [1 ,2 ]
Andersen, K. E. [1 ,2 ]
机构
[1] Univ Southern Denmark, Odense Univ Hosp, Dept Dermatol, DK-5000 Odense C, Denmark
[2] Univ Southern Denmark, Odense Univ Hosp, Allergy Ctr, DK-5000 Odense C, Denmark
关键词
ATOPIC DISEASES; DANISH POPULATION; ADULT-POPULATION; SENSITIZATION; ECZEMA; HAND;
D O I
10.1111/bjd.12065
中图分类号
R75 [皮肤病学与性病学];
学科分类号
100206 ;
摘要
Background A cohort of 1501 unselected 8th grade schoolchildren was established 15 years ago with the aim to follow the course of contact allergy and allergic contact dermatitis (ACD) from school age into adult life. To date no studies have evaluated incidence rates and persistence of contact allergy and ACD in an unselected population from adolescence to adulthood. Objectives To estimate the incidence rates and persistence of contact allergy and ACD from adolescence to adulthood, and the point prevalence in adulthood. Methods In total, 1206 young adults from the cohort were contacted and asked to complete a questionnaire and participate in a clinical examination including patch testing with TRUE Test (R). The questionnaire was answered by 899 (74.6%), however, only 442 (36.7%) of those invited participated in patch testing. Results Over the 15-year period the incidence rates of contact allergy and ACD were 13.4% and 7.8%, respectively. The point prevalence of contact allergy was 20.1%, and present or past ACD was found in 12.9% of those followed. Nickel was the most common contact allergen (11.8%), followed by cobalt (2.3%), colophony (2.0%), thiomersal (1.4%) and p-phenylenediamine (1.1%). Most nickel reactions were persistent, and a significant number of new nickel sensitizations were found. Fragrance mix I reactions from adolescence could not be reproduced. Conclusions From adolescence to adulthood the incidence rates of contact allergy and ACD were high. Nickel was still the most common contact allergen, and new sensitizations occurred despite the European Union nickel regulation. Fragrance mix I was a poor marker for history of eczematous skin reaction to perfumed products.
引用
收藏
页码:318 / 325
页数:8
相关论文
共 25 条
[1]   Statistical evaluation of the persistence of acquired hypersensitivity by standardized patch tests [J].
Ayala, F ;
Balato, N ;
Lembo, G ;
Patruno, C ;
Fabbrocini, G ;
Nofroni, I ;
Magliocchetti, N ;
Schena, D ;
Rafanelli, A ;
Seidenari, S ;
Motolese, A ;
Angelini, G ;
Tosti, A ;
Saccabusi, S ;
Pigatto, P ;
Lisi, P .
CONTACT DERMATITIS, 1996, 34 (05) :354-358
[2]   Allergic contact sensitization in the general adult population: a population-based study from Northern Norway [J].
Dotterud, Lars Kare ;
Smith-Sivertsen, Tone .
CONTACT DERMATITIS, 2007, 56 (01) :10-15
[3]  
Hindsen M, 1999, Am J Contact Dermat, V10, P62, DOI 10.1016/S1046-199X(99)90001-5
[4]   Course of contact allergy in consecutive eczema patients patch tested with TRUE Test™ panels 1 and 2 at least twice over a 12-year period [J].
Jensen, CD ;
Andersen, KE .
CONTACT DERMATITIS, 2005, 52 (05) :242-246
[5]  
Johansen JD, 2011, CONTACT DERMATITIS, FIFTH EDITION, P1, DOI 10.1007/978-3-642-03827-3
[6]   The outcome of an additional patch-test reading on days 6 or 7 [J].
Jonker, MJ ;
Bruynzeel, DP .
CONTACT DERMATITIS, 2000, 42 (06) :330-335
[7]   The occurrence of atopic dermatitis in North Europe: An international questionnaire study [J].
Larsen, FS ;
Diepgen, T ;
Svensson, A .
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, 1996, 34 (05) :760-764
[8]   Is contact allergy in man lifelong? An overview of patch test follow-ups [J].
Lee, EE ;
Maibach, HI .
CONTACT DERMATITIS, 2001, 44 (03) :137-139
[9]   Time trends in Swedish patch test data from 1992 to 2000. A multi-centre study based on age-adjusted and sex-adjusted results of the Swedish standard series [J].
Lindberg, Magnus ;
Edman, Bjorn ;
Fischer, Torkel ;
Stenberg, Berndt .
CONTACT DERMATITIS, 2007, 56 (04) :205-210
[10]   REGULATION OF NICKEL EXPOSURE IN DENMARK [J].
MENNE, T ;
RASMUSSEN, K .
CONTACT DERMATITIS, 1990, 23 (01) :57-58