Investigation of noncovalent complexes between β-cyclodextrin and polyamide acids containing N-methylpyrrole and N-methylimidazole by electrospray ionization mass spectrometry

被引：10
|
作者：
Li, HH [1 ]
Zhou, J [1 ]
Tang, FL [1 ]
Yuan, G [1 ]
机构：
[1] Peking Univ, Dept Biol Chem, Key Lab Bioorgan Chem & Mol Engn, Minist Educ,Coll Chem, Beijing 100871, Peoples R China
来源：
JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY | 2006年 / 17卷 / 01期
基金：
中国国家自然科学基金;
关键词：
D O I：
10.1016/j.jasms.2005.08.011
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
Electrospray ionization (ESI) mass spectrometry was utilized to investigate noncovalent complexes between beta-cyclodextrin (beta-CD) and five novel polyamide acids containing N-methylpyrrole and N-methylimidazole. The 1:1 binding mode was specified by examining the binding stoichiometry from ESI mass spectra. It found that polyamide acids with P-CD have binding affinities in the order: ImImIm beta COOH > ImPyIm beta COOH > ImPyPy beta COOH > PyPyPy beta COOH > NO(2)PyPyPy beta COOH. The method gives, simultaneously, the binding constants between P-CD and polyamide acids based on a novel linear equation.
引用
收藏
页码：9 / 14
页数：6
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