Comparative patterns of cognitive performance amongst opioid maintenance patients, abstinent opioid users and non-opioid users

被引:44
作者
Darke, Shane [1 ]
McDonald, Skye [2 ]
Kaye, Sharlene [1 ]
Torok, Michelle [1 ]
机构
[1] Univ New S Wales, Natl Drug & Alcohol Res Ctr, Sydney, NSW 2052, Australia
[2] Univ New S Wales, Sch Psychol, Sydney, NSW 2052, Australia
基金
英国医学研究理事会;
关键词
Opioids; Cognitive; Impairment; Treatment; Neuropsychology; HEROIN USERS; DECISION-MAKING; METHADONE; BRAIN; AMPHETAMINE; IMPAIRMENT; IMPACT; BUPRENORPHINE; ALCOHOLISM; ADDICTION;
D O I
10.1016/j.drugalcdep.2012.05.032
中图分类号
R194 [卫生标准、卫生检查、医药管理];
学科分类号
摘要
Background: To compare the cognitive performances of maintenance patients (MAIN), abstinent ex-users (ABST) and healthy non-heroin using controls (CON). Methods: Case control study of 125 MAIN (94 subjects maintained on methadone, 31 on buprenorphine), 50 ABST and 50 CON. Neuropsychological tests measuring executive function, working memory, information processing speed, verbal learning and non-verbal learning were administered. Results: There were no differences between the cognitive profiles of those maintained on methadone or buprenorphine on any administered test. After controlling for confounders, the MAIN group had poorer performance than controls in six of the 13 administered tests, and were poorer than the ABST group in five. The MAIN group exhibited poorer performance in the Haylings Sentence Completion, Matrix Reasoning, Digit Symbol, Logical Memory (immediate and delayed recall), and the Complex Figure Test (immediate recall). There were no differences between the ABST and CON groups on any of the administered tests. Conclusions: Poorer cognitive performance, across a range of test and domains, was seen amongst maintenance patients, regardless of their maintenance drug. This is a group that is likely might benefit from approaches for managing individuals with cognitive and behavioural difficulties arising from brain dysfunction. (C) 2012 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码:309 / 315
页数:7
相关论文
共 50 条
[1]  
[Anonymous], 1997, WESCHLER MEMORY SCAL
[2]  
[Anonymous], 2009, PASW STAT 18 0
[3]  
[Anonymous], BR J ADDICT
[4]  
[Anonymous], 2009, PHARMACOTHERAPIES TR
[5]   Predisposition to accelerated Alzheimer-related changes in the brains of human immunodeficiency virus negative opiate abusers [J].
Anthony, Iain C. ;
Norrby, Katherine E. ;
Dingwall, Tommy ;
Carnie, Frances W. ;
Millar, Tracey ;
Arango, Juan Carlos ;
Robertson, Roy ;
Bell, Jeanne E. .
BRAIN, 2010, 133 :3685-3698
[6]   VEdeTTE, a longitudinal study on effectiveness of treatments for heroin addiction in Italy: Study protocol and characteristics of study population [J].
Bargagli, Anna Maria ;
Faggiano, Fabrizio ;
Amato, Laura ;
Salamina, Giuseppe ;
Davoli, Marina ;
Mathis, Federica ;
Cuomo, Luca ;
Schifano, Patrizia ;
Burroni, Paola ;
Perucci, Carlo Alberto .
SUBSTANCE USE & MISUSE, 2006, 41 (14) :1861-1879
[7]   Retrospective recall of heroin initiation and the impact on peer networks [J].
Best, David ;
Manning, Victoria ;
Strang, John .
ADDICTION RESEARCH & THEORY, 2007, 15 (04) :397-410
[8]  
Bowden S., 1992, PSYCHOL BULL, V107, P355
[9]   Executive functions and risky decision-making in patients with opiate dependence [J].
Brand, Matthias ;
Roth-Bauer, Martina ;
Driessen, Martin ;
Markowitsch, Hans J. .
DRUG AND ALCOHOL DEPENDENCE, 2008, 97 (1-2) :64-72
[10]   Widespread axonal damage in the brain of drug abusers as evidenced by accumulation of β-amyloid precursor protein (β-APP):: an immunohistochemical investigation [J].
Buettner, Andreas ;
Rohrmoser, Katharina ;
Mall, Gita ;
Penning, Randolph ;
Weis, Serge .
ADDICTION, 2006, 101 (09) :1339-1346