Dietary Weight Loss, Exercise, and Oxidative Stress in Postmenopausal Women: A Randomized Controlled Trial

被引:33
作者
Duggan, Catherine [1 ]
Tapsoba, Jean de Dieu [1 ]
Wang, Ching-Yun [1 ,2 ]
Campbell, Kristin L. [3 ]
Foster-Schubert, Karen [4 ]
Gross, Myron D. [5 ]
McTiernan, Anne [1 ,2 ]
机构
[1] Fred Hutchinson Canc Res Ctr, Publ Hlth Sci, 1124 Columbia St, Seattle, WA 98104 USA
[2] Univ Washington, Sch Publ Hlth, Seattle, WA 98195 USA
[3] Univ British Columbia, Fac Med, Vancouver, BC, Canada
[4] Univ Washington, Sch Med, Seattle, WA USA
[5] Univ Minnesota, Minneapolis, MN USA
关键词
LOW-DENSITY-LIPOPROTEIN; BREAST-CANCER RISK; METABOLIC SYNDROME; URINARY ISOPROSTANE; PHYSICAL-ACTIVITY; INFLAMMATION; OBESITY; BIOMARKERS; MECHANISMS; PRODUCTS;
D O I
10.1158/1940-6207.CAPR-16-0163
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Oxidative stress, a potential mechanism linking obesity and cancer, results from an imbalance between activation/inactivation of reactive oxygen species, byproducts of cellular metabolism. In a randomized controlled trial, we investigated effects of diet and/or exercise on biomarkers of oxidative stress. A total of 439 overweight/obese [body mass index (BMI) > 25 kg/m(2)] postmenopausal women, ages 50 of 75 years, were randomized to 12 months of (i) reduced-calorie weight loss diet ("diet"; n = 118); (ii) moderate-to-vigorous intensity aerobic exercise ("exercise"; n = 117); (iii) combined diet and exercise intervention ("diet + exercise"; n = 117); or (iv) control (n = 87). Outcomes were circulating markers of oxidative stress, including fluorescent oxidation products (FOP), F-2-isoprostanes, and oxidized low-density lipoprotein (LDL). On average, participants were 57.9 years, with a BMI of 30.9 kg/m(2). F-2-isprostanes were significantly reduced in the diet (-22.7%, P < 0.0002) and diet + exercise (-23.5%, P < 0.0001) arms versus controls (-2.99%) and nonsignificantly reduced in the exercise arm (-14.5%, P = 0.01). Participants randomized to the diet and diet + exercise arms had significant increases in levels of FOP [control -5.81%; diet +14.77% (P = 0.0001); diet + exercise +17.45%, (P = 0.0001)]. In secondary analyses, increasing weight loss was statistically significantly associated with linear trends of greater reductions in oxidized LDL and in F-2-isoprostanes and increases in FOP. Compared with controls, exercise participants whose maximal oxygen consumption increased had significant decreases in levels of F-2-isoprostanes and in oxidized LDL and increases in FOP. Dietary weight loss, with or without exercise, significantly reduced some markers of oxidative stress in postmenopausal women. (C) 2016 AACR.
引用
收藏
页码:835 / 843
页数:9
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