The Role of Osteopontin in Amyotrophic Lateral Sclerosis: A Systematic Review
被引:2
作者:
Mousavi, Seyed Vahid
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机构:
Univ Tehran Med Sci, Students Sci Res Ctr, Tehran, Iran
Universal Sci Educ & Res Network USERN, NeuroImmunol Res Assoc NIRA, Tehran, IranUniv Tehran Med Sci, Students Sci Res Ctr, Tehran, Iran
Mousavi, Seyed Vahid
[1
,2
]
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Agah, Elmira
[1
,2
]
Tafakhori, Abbas
论文数: 0引用数: 0
h-index: 0
机构:
Univ Tehran Med Sci, Iranian Ctr Neurol Res, Neurosci Inst, Tehran, IranUniv Tehran Med Sci, Students Sci Res Ctr, Tehran, Iran
Tafakhori, Abbas
[3
]
机构:
[1] Univ Tehran Med Sci, Students Sci Res Ctr, Tehran, Iran
[2] Universal Sci Educ & Res Network USERN, NeuroImmunol Res Assoc NIRA, Tehran, Iran
[3] Univ Tehran Med Sci, Iranian Ctr Neurol Res, Neurosci Inst, Tehran, Iran
Context: Osteopontin (OPN) is a matrix phosphoprotein expressed by a variety of tissues and cells, including the immune system and the nervous system. Previous studies have shown that OPN may have a role in neurodegenerative diseases, including multiple sclerosis, Parkinson's disease, and Alzheimer's disease. Objectives: The present study aimed to systematically review studies investigating the role of OPN in amyotrophic lateral sclerosis (ALS) patients or the disease animal model. Evidence Acquisition: We searched the Cochrane Library, PubMed, Web of Science, and Scopus to find relevant articles published up to January 20, 2019. Both human and animal model studies of ALS were considered. Results: A total of nine articles (four human studies and five animal model studies) were included. Two of the human studies reported that the CSF levels of OPN were higher among ALS patients compared to controls. The other two human studies found that OPN levels in cortical neurons did not differ significantly between ALS cases and the non-neurological control group. One of the studies found that the expression level of OPN in astrocytes was similar between ALS patients and the control group, but the level of microglial OPN significantly increased in ALS cases. Four of the animal model studies reported that the expression of OPN mRNA in spinal cord microglia significantly increased during the disease progression. The remaining animal model study found that OPN was selectively expressed by fast fatigue-resistant and slow motor neurons (MNs), which are resistant to ALS, and that the OPN expression was low among fast-fatigable MNs. Conclusions: Prompt microglial activation is a hallmark pathology of ALS, and OPN is among the most widely expressed proteins by these activated glial cells. Therefore, OPN might have a role in ALS pathogenesis. The existing evidence is not sufficient to justify whether OPN has a neurotoxic or neuroprotective role in ALS. We encourage researchers to investigate the role of OPN in ALS pathogenesis more extensively.
机构:
Univ Tehran Med Sci, Students Sci Res Ctr, Tehran, Iran
USERN, NeuroImmunol Res Assoc NIRA, Tehran, IranUniv Tehran Med Sci, Students Sci Res Ctr, Tehran, Iran
Zardoui, Arshia
;
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Saghazadeh, Amene
;
Ahmadi, Mona
论文数: 0引用数: 0
h-index: 0
机构:Univ Tehran Med Sci, Students Sci Res Ctr, Tehran, Iran
Ahmadi, Mona
;
Tafakhori, Abbas
论文数: 0引用数: 0
h-index: 0
机构:
USERN, NeuroImmunol Res Assoc NIRA, Tehran, Iran
Univ Tehran Med Sci, ICNR, Tehran, IranUniv Tehran Med Sci, Students Sci Res Ctr, Tehran, Iran
Tafakhori, Abbas
;
Rezaei, Nima
论文数: 0引用数: 0
h-index: 0
机构:
Univ Tehran Med Sci, Childrens Med Ctr, Res Ctr Immunodeficiencies RCID, Tehran, Iran
USERN, NIIMA, Tehran, IranUniv Tehran Med Sci, Students Sci Res Ctr, Tehran, Iran
机构:
Harvard Univ, Sch Med, Immune Dis Inst, Dept Pathol, Boston, MA 02115 USAHarvard Univ, Sch Med, Immune Dis Inst, Dept Pathol, Boston, MA 02115 USA
Chiu, Isaac M.
;
Chen, Adam
论文数: 0引用数: 0
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机构:
Massachusetts Gen Hosp, Day Neuromuscular Res Lab, Charlestown, MA 02129 USAHarvard Univ, Sch Med, Immune Dis Inst, Dept Pathol, Boston, MA 02115 USA
Chen, Adam
;
Zheng, Yi
论文数: 0引用数: 0
h-index: 0
机构:
Harvard Univ, Sch Med, Immune Dis Inst, Dept Pathol, Boston, MA 02115 USAHarvard Univ, Sch Med, Immune Dis Inst, Dept Pathol, Boston, MA 02115 USA
Zheng, Yi
;
Kosaras, Bela
论文数: 0引用数: 0
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机构:
Harvard Univ, Sch Med, Beth Israel Deaconess Med Ctr, Boston, MA 02115 USAHarvard Univ, Sch Med, Immune Dis Inst, Dept Pathol, Boston, MA 02115 USA
Kosaras, Bela
;
Tsiftsoglou, Stefanos A.
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机构:
Harvard Univ, Sch Med, Immune Dis Inst, Dept Pathol, Boston, MA 02115 USAHarvard Univ, Sch Med, Immune Dis Inst, Dept Pathol, Boston, MA 02115 USA
Tsiftsoglou, Stefanos A.
;
Vartanian, Timothy K.
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Harvard Univ, Sch Med, Beth Israel Deaconess Med Ctr, Boston, MA 02115 USAHarvard Univ, Sch Med, Immune Dis Inst, Dept Pathol, Boston, MA 02115 USA
Vartanian, Timothy K.
;
Brown, Robert H., Jr.
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h-index: 0
机构:
Massachusetts Gen Hosp, Day Neuromuscular Res Lab, Charlestown, MA 02129 USAHarvard Univ, Sch Med, Immune Dis Inst, Dept Pathol, Boston, MA 02115 USA
Brown, Robert H., Jr.
;
Carroll, Michael C.
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机构:
Harvard Univ, Sch Med, Immune Dis Inst, Dept Pathol, Boston, MA 02115 USAHarvard Univ, Sch Med, Immune Dis Inst, Dept Pathol, Boston, MA 02115 USA
机构:Massachusetts Gen Hosp, Ctr Immunol & Inflammatory Dis, Boston, MA 02114 USA
Hickman, Suzanne
;
Izzy, Saef
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机构:Massachusetts Gen Hosp, Ctr Immunol & Inflammatory Dis, Boston, MA 02114 USA
Izzy, Saef
;
Sen, Pritha
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机构:Massachusetts Gen Hosp, Ctr Immunol & Inflammatory Dis, Boston, MA 02114 USA
Sen, Pritha
;
Morsett, Liza
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机构:Massachusetts Gen Hosp, Ctr Immunol & Inflammatory Dis, Boston, MA 02114 USA
Morsett, Liza
;
El Khoury, Joseph
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机构:
Massachusetts Gen Hosp, Ctr Immunol & Inflammatory Dis, Boston, MA 02114 USAMassachusetts Gen Hosp, Ctr Immunol & Inflammatory Dis, Boston, MA 02114 USA
机构:
Univ Tehran Med Sci, Students Sci Res Ctr, Tehran, Iran
USERN, NeuroImmunol Res Assoc NIRA, Tehran, IranUniv Tehran Med Sci, Students Sci Res Ctr, Tehran, Iran
Zardoui, Arshia
;
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机构:
Saghazadeh, Amene
;
Ahmadi, Mona
论文数: 0引用数: 0
h-index: 0
机构:Univ Tehran Med Sci, Students Sci Res Ctr, Tehran, Iran
Ahmadi, Mona
;
Tafakhori, Abbas
论文数: 0引用数: 0
h-index: 0
机构:
USERN, NeuroImmunol Res Assoc NIRA, Tehran, Iran
Univ Tehran Med Sci, ICNR, Tehran, IranUniv Tehran Med Sci, Students Sci Res Ctr, Tehran, Iran
Tafakhori, Abbas
;
Rezaei, Nima
论文数: 0引用数: 0
h-index: 0
机构:
Univ Tehran Med Sci, Childrens Med Ctr, Res Ctr Immunodeficiencies RCID, Tehran, Iran
USERN, NIIMA, Tehran, IranUniv Tehran Med Sci, Students Sci Res Ctr, Tehran, Iran
机构:
Harvard Univ, Sch Med, Immune Dis Inst, Dept Pathol, Boston, MA 02115 USAHarvard Univ, Sch Med, Immune Dis Inst, Dept Pathol, Boston, MA 02115 USA
Chiu, Isaac M.
;
Chen, Adam
论文数: 0引用数: 0
h-index: 0
机构:
Massachusetts Gen Hosp, Day Neuromuscular Res Lab, Charlestown, MA 02129 USAHarvard Univ, Sch Med, Immune Dis Inst, Dept Pathol, Boston, MA 02115 USA
Chen, Adam
;
Zheng, Yi
论文数: 0引用数: 0
h-index: 0
机构:
Harvard Univ, Sch Med, Immune Dis Inst, Dept Pathol, Boston, MA 02115 USAHarvard Univ, Sch Med, Immune Dis Inst, Dept Pathol, Boston, MA 02115 USA
Zheng, Yi
;
Kosaras, Bela
论文数: 0引用数: 0
h-index: 0
机构:
Harvard Univ, Sch Med, Beth Israel Deaconess Med Ctr, Boston, MA 02115 USAHarvard Univ, Sch Med, Immune Dis Inst, Dept Pathol, Boston, MA 02115 USA
Kosaras, Bela
;
Tsiftsoglou, Stefanos A.
论文数: 0引用数: 0
h-index: 0
机构:
Harvard Univ, Sch Med, Immune Dis Inst, Dept Pathol, Boston, MA 02115 USAHarvard Univ, Sch Med, Immune Dis Inst, Dept Pathol, Boston, MA 02115 USA
Tsiftsoglou, Stefanos A.
;
Vartanian, Timothy K.
论文数: 0引用数: 0
h-index: 0
机构:
Harvard Univ, Sch Med, Beth Israel Deaconess Med Ctr, Boston, MA 02115 USAHarvard Univ, Sch Med, Immune Dis Inst, Dept Pathol, Boston, MA 02115 USA
Vartanian, Timothy K.
;
Brown, Robert H., Jr.
论文数: 0引用数: 0
h-index: 0
机构:
Massachusetts Gen Hosp, Day Neuromuscular Res Lab, Charlestown, MA 02129 USAHarvard Univ, Sch Med, Immune Dis Inst, Dept Pathol, Boston, MA 02115 USA
Brown, Robert H., Jr.
;
Carroll, Michael C.
论文数: 0引用数: 0
h-index: 0
机构:
Harvard Univ, Sch Med, Immune Dis Inst, Dept Pathol, Boston, MA 02115 USAHarvard Univ, Sch Med, Immune Dis Inst, Dept Pathol, Boston, MA 02115 USA
机构:Massachusetts Gen Hosp, Ctr Immunol & Inflammatory Dis, Boston, MA 02114 USA
Hickman, Suzanne
;
Izzy, Saef
论文数: 0引用数: 0
h-index: 0
机构:Massachusetts Gen Hosp, Ctr Immunol & Inflammatory Dis, Boston, MA 02114 USA
Izzy, Saef
;
Sen, Pritha
论文数: 0引用数: 0
h-index: 0
机构:Massachusetts Gen Hosp, Ctr Immunol & Inflammatory Dis, Boston, MA 02114 USA
Sen, Pritha
;
Morsett, Liza
论文数: 0引用数: 0
h-index: 0
机构:Massachusetts Gen Hosp, Ctr Immunol & Inflammatory Dis, Boston, MA 02114 USA
Morsett, Liza
;
El Khoury, Joseph
论文数: 0引用数: 0
h-index: 0
机构:
Massachusetts Gen Hosp, Ctr Immunol & Inflammatory Dis, Boston, MA 02114 USAMassachusetts Gen Hosp, Ctr Immunol & Inflammatory Dis, Boston, MA 02114 USA