Applications of luminescent inorganic and organometallic transition metal complexes as biomolecular and cellular probes

被引：341
作者：
Lo, Kenneth Kam-Wing [1 ]
Choi, Alex Wing-Tat [1 ]
Law, Wendell Ho-Tin [1 ]
机构：
[1] City Univ Hong Kong, Dept Biol & Chem, Kowloon, Hong Kong, Peoples R China
来源：
DALTON TRANSACTIONS | 2012年 / 41卷 / 20期
关键词：
IRIDIUM(III) POLYPYRIDINE COMPLEXES; AMIDODIPYRIDOQUINOXALINE BIOTIN COMPLEXES; CYCLOMETALATED PLATINUM(II) COMPLEXES; PROTEIN-BINDING PROPERTIES; MOLECULAR LIGHT SWITCH; ELECTROCHEMICAL PROPERTIES; IN-VITRO; PHOTOPHYSICAL PROPERTIES; DIIMINE COMPLEXES; LABELING REAGENTS;
D O I：
10.1039/c2dt11892k
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
The rich photophysical properties of luminescent inorganic and organometallic transition metal complexes, such as their intense, long-lived, and environment-sensitive emission, render them excellent candidates for biological and cellular studies. In this Perspective, we review examples of biological probes derived from luminescent transition metal complexes with a d(6), d(8), or d(10) metal center. The design of luminescent covalent labels and noncovalent probes for protein molecules is discussed. Additionally, the recent applications of these complexes as cellular probes and bioimaging reagents are described. Emphasis is put on the structural features, photophysical behavior, biomolecular interactions, cellular uptake, and intracellular localization properties of luminescent transition metal complexes.
引用
收藏
页码：6021 / 6047
页数：27
相关论文
共 133 条
[51]   A Nonemissive Iridium(III) Complex That Specifically Lights-Up the Nuclei of Living Cells [J].
Li, Chunyan ;
Yu, Mengxiao ;
Sun, Yun ;
Wu, Yongquan ;
Huang, Chunhui ;
Li, Fuyou .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2011, 133 (29) :11231-11239
[52]   Modification of Luminescent Iridium(III) Polypyridine Complexes with Discrete Poly(ethylene glycol) (PEG) Pendants: Synthesis, Emissive Behavior, Intracellular Uptake, and PEGylation Properties [J].
Li, Steve Po-Yam ;
Liu, Hua-Wei ;
Zhang, Kenneth Yin ;
Lo, Kenneth Kam-Wing .
CHEMISTRY-A EUROPEAN JOURNAL, 2010, 16 (28) :8329-8339
[53]   Metal Complexes as DNA Intercalators [J].
Liu, Hong-Ke ;
Sadler, Peter J. .
ACCOUNTS OF CHEMICAL RESEARCH, 2011, 44 (05) :349-359
[54]   Cyclometalated Iridium(III) Bipyridine Complexes Functionalized with an N-Methylamino-oxy Group as Novel Phosphorescent Labeling Reagents for Reducing Sugars [J].
Liu, Hua-Wei ;
Zhang, Kenneth Yin ;
Law, Wendell Ho-Tin ;
Lo, Kenneth Kam-Wing .
ORGANOMETALLICS, 2010, 29 (16) :3474-3476
[55]  
Ljung K, 2002, PLANT MOL BIOL, V50, P309, DOI [10.1023/A:1015298812300, 10.1023/A:1016024017872]
[56]   Synthesis, characterization, and properties of luminescent organoiridium(III) polypyridine complexes appended with an alkyl chain and their interactions with lipid bilayers, surfactants, and living cells [J].
Lo, Kenneth Kam-Wing ;
Lee, Pui-Kei ;
Lau, Jason Shing-Yip .
ORGANOMETALLICS, 2008, 27 (13) :2998-3006
[57]   Exploitation of the dual-emissive properties of cyclometalated Iridium(III)-polypyridine complexes in the development of luminescent biological probes [J].
Lo, Kenneth Kam-Wing ;
Zhang, Kenneth Yin ;
Leung, Siu-Kit ;
Tang, Man-Chung .
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2008, 47 (12) :2213-2216
[58]   Rhenium(I) polypyridine biotin isothiocyanate complexes as the first luminescent biotinylation reagents: Synthesis, photophysical properties, biological labeling, cytotoxicity, and imaging studies [J].
Lo, Kenneth Kam-Wing ;
Louie, Man-Wai ;
Sze, Ka-Shing ;
Lau, Jason Shing-Yip .
INORGANIC CHEMISTRY, 2008, 47 (02) :602-611
[59]   Luminescent biological probes derived from ruthenium(II) estradiol polypyridine complexes [J].
Lo, Kenneth Kam-Wing ;
Lee, Terence Kwok-Ming ;
Lau, Jason Shing-Yip ;
Poon, Wing-Lin ;
Cheng, Shuk-Han .
INORGANIC CHEMISTRY, 2008, 47 (01) :200-208
[60]   Synthesis, photophysical and electrochemical properties, and protein-binding studies of luminescent cyclometalated Iridium(III) bipyridine estradiol conjugates [J].
Lo, Kenneth Kam-Wing ;
Zhang, Kenneth Yin ;
Chung, Chi-Keung ;
Kwok, Karen Ying .
CHEMISTRY-A EUROPEAN JOURNAL, 2007, 13 (25) :7110-7120
12345678910