Applications of luminescent inorganic and organometallic transition metal complexes as biomolecular and cellular probes

被引:341
作者
Lo, Kenneth Kam-Wing [1 ]
Choi, Alex Wing-Tat [1 ]
Law, Wendell Ho-Tin [1 ]
机构
[1] City Univ Hong Kong, Dept Biol & Chem, Kowloon, Hong Kong, Peoples R China
关键词
IRIDIUM(III) POLYPYRIDINE COMPLEXES; AMIDODIPYRIDOQUINOXALINE BIOTIN COMPLEXES; CYCLOMETALATED PLATINUM(II) COMPLEXES; PROTEIN-BINDING PROPERTIES; MOLECULAR LIGHT SWITCH; ELECTROCHEMICAL PROPERTIES; IN-VITRO; PHOTOPHYSICAL PROPERTIES; DIIMINE COMPLEXES; LABELING REAGENTS;
D O I
10.1039/c2dt11892k
中图分类号
O61 [无机化学];
学科分类号
070301 ; 081704 ;
摘要
The rich photophysical properties of luminescent inorganic and organometallic transition metal complexes, such as their intense, long-lived, and environment-sensitive emission, render them excellent candidates for biological and cellular studies. In this Perspective, we review examples of biological probes derived from luminescent transition metal complexes with a d(6), d(8), or d(10) metal center. The design of luminescent covalent labels and noncovalent probes for protein molecules is discussed. Additionally, the recent applications of these complexes as cellular probes and bioimaging reagents are described. Emphasis is put on the structural features, photophysical behavior, biomolecular interactions, cellular uptake, and intracellular localization properties of luminescent transition metal complexes.
引用
收藏
页码:6021 / 6047
页数:27
相关论文
共 133 条
[1]   3-Chloromethylpyridyl bipyridine fac-tricarbonyl rhenium:: a thiol-reactive luminophore for fluorescence microscopy accumulates in mitochondria [J].
Amoroso, Angelo J. ;
Arthur, Richard J. ;
Coogan, Michael P. ;
Court, Jonathan B. ;
Fernandez-Moreira, Vanesa ;
Hayes, Anthony J. ;
Lloyd, David ;
Millet, Coralie ;
Pope, Simon J. A. .
NEW JOURNAL OF CHEMISTRY, 2008, 32 (07) :1097-1102
[2]   Naphthalimide gold(I) phosphine complexes as anticancer metallodrugs [J].
Bagowski, Christoph P. ;
You, Ya ;
Scheffler, Heike ;
Vlecken, Danielle H. ;
Schmitza, Daan J. ;
Ott, Ingo .
DALTON TRANSACTIONS, 2009, (48) :10799-10805
[3]   Complexes in context: Attempting to control the cellular uptake and localisation of rhenium fac-tricarbonyl polypyridyl complexes [J].
Balasingham, Rebeca G. ;
Coogan, Michael P. ;
Thorp-Greenwood, Flora L. .
DALTON TRANSACTIONS, 2011, 40 (44) :11663-11674
[4]  
Balzani C., 2007, TOPICS CURRENT CHEM, V280-281
[5]  
Barigelletti F, 2010, PHOTOCHEM-SPEC PERIO, V38, P234, DOI 10.1039/9781849730860-00234
[6]   Luminescence studies of the intracellular distribution of a dinuclear gold(I) N-heterocyclic carbene complex [J].
Barnard, Peter J. ;
Wedlock, Louise E. ;
Baker, Murray V. ;
Berners-Price, Susan J. ;
Joyce, David A. ;
Skelton, Brian W. ;
Steer, James H. .
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2006, 45 (36) :5966-5970
[7]  
Bartel Bonnie, 1997, Annu Rev Plant Physiol Plant Mol Biol, V48, P51, DOI 10.1146/annurev.arplant.48.1.51
[8]   Metal complexes for DNA-mediated charge transport [J].
Barton, Jacqueline K. ;
Olmon, Eric D. ;
Sontz, Pamela A. .
COORDINATION CHEMISTRY REVIEWS, 2011, 255 (7-8) :619-634
[9]   Picosecond photoreduction of inducible nitric oxide synthase by rhenium(I)-diimine wires [J].
Belliston-Bittner, W ;
Dunn, AR ;
Nguyen, YHL ;
Stuehr, DJ ;
Winkler, JR ;
Gray, HB .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2005, 127 (45) :15907-15915
[10]   Phototriggering Electron Flow through ReI-modified Pseudomonas aeruginosa Azurins [J].
Blanco-Rodriguez, Ana Maria ;
Di Bilio, Angel J. ;
Shih, Crystal ;
Museth, Anna Katrine ;
Clark, Ian P. ;
Towrie, Michael ;
Cannizzo, Andrea ;
Sudhamsu, Jawahar ;
Crane, Brian R. ;
Sykora, Jan ;
Winkler, Jay R. ;
Gray, Harry B. ;
Zalis, Stanislav ;
Vlcek, Antonin, Jr. .
CHEMISTRY-A EUROPEAN JOURNAL, 2011, 17 (19) :5350-5361