Applications of luminescent inorganic and organometallic transition metal complexes as biomolecular and cellular probes

被引：341

作者：

Lo, Kenneth Kam-Wing ^{[1
]}

Choi, Alex Wing-Tat ^{[1
]}

Law, Wendell Ho-Tin ^{[1
]}

机构：

[1] City Univ Hong Kong, Dept Biol & Chem, Kowloon, Hong Kong, Peoples R China

来源：

DALTON TRANSACTIONS | 2012年 / 41卷 / 20期

关键词：

IRIDIUM(III) POLYPYRIDINE COMPLEXES; AMIDODIPYRIDOQUINOXALINE BIOTIN COMPLEXES; CYCLOMETALATED PLATINUM(II) COMPLEXES; PROTEIN-BINDING PROPERTIES; MOLECULAR LIGHT SWITCH; ELECTROCHEMICAL PROPERTIES; IN-VITRO; PHOTOPHYSICAL PROPERTIES; DIIMINE COMPLEXES; LABELING REAGENTS;

D O I：

10.1039/c2dt11892k

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

The rich photophysical properties of luminescent inorganic and organometallic transition metal complexes, such as their intense, long-lived, and environment-sensitive emission, render them excellent candidates for biological and cellular studies. In this Perspective, we review examples of biological probes derived from luminescent transition metal complexes with a d(6), d(8), or d(10) metal center. The design of luminescent covalent labels and noncovalent probes for protein molecules is discussed. Additionally, the recent applications of these complexes as cellular probes and bioimaging reagents are described. Emphasis is put on the structural features, photophysical behavior, biomolecular interactions, cellular uptake, and intracellular localization properties of luminescent transition metal complexes.

引用

页码：6021 / 6047

页数：27

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