Pharmacological activities of some new polycyclic triazolopyrazolopyridazine derivatives

被引：16

作者：

Bahashwan, Saleh A. ^{[1
]}

Al-Harbi, Naif O. ^{[2
]}

Fayed, Ahmed A. ^{[1
,3
]}

Amr, Abd El-Galil E. ^{[3
,4
]}

Shadid, Khalid A. ^{[1
,5
]}

Alalawi, Ali M. ^{[1
]}

Bassati, Ibrahim M. S. ^{[1
]}

机构：

[1] Taibah Univ, Coll Med Rehabil Sci, Dept Pharm, Al Munawarrah, Saudi Arabia

[2] King Saud Univ, Coll Pharm, Dept Pharmacol, Riyadh 11451, Saudi Arabia

[3] Natl Res Ctr, Cairo, Egypt

[4] King Saud Univ, Coll Pharm, DEDC, Riyadh, Saudi Arabia

[5] Al Ahliyya Amman Univ, Fac Pharm & Med Sci, Amman, Jordan

来源：

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES | 2012年 / 51卷 / 1-2期

关键词：

Heterocyclic candidates; Polycyclic ring systems; Anti-inflammatory; Analgesic; Antimicrobial activities; LOCAL-ANESTHETIC ACTIVITY; ANTIINFLAMMATORY ACTIVITIES; ANTIPARKINSONIAN AGENTS; PYRIMIDINE-DERIVATIVES; ANTIMICROBIAL ACTIVITY; ANTITUMOR; PYRIDINE; ACID; ANTICONVULSANT; INHIBITORS;

D O I：

10.1016/j.ijbiomac.2012.05.002

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In continuation of our previous work, a novel series of polycyclic derivatives were synthesized and their anti-inflammatory, analgesic and antimicrobial activities were evaluated. Initially the acute toxicity of the compounds was assayed via the determination of their LD50. Some of the newly compounds exhibited better biological and pharmacological activities than the reference controls with low toxicity (LD50). The structure of the new compounds has been established on the bases of chemical and spectroscopic evidences. The detailed synthesis, spectroscopic data, LD50 and pharmacological activities of the synthesized compounds were reported. (c) 2012 Elsevier B.V. All rights reserved.

引用

页码：7 / 17

页数：11

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