A prodigiosin from the roseophilin producer Streptomyces griseoviridis

被引：51

作者：

Kawasaki, Takashi ^{[1
]}

Sakurai, Fumi ^{[1
]}

Hayakawa, Yoichi ^{[1
]}

机构：

[1] Tokyo Univ Sci, Fac Pharmaceut Sci, Chiba 2788510, Japan

来源：

JOURNAL OF NATURAL PRODUCTS | 2008年 / 71卷 / 07期

关键词：

D O I：

10.1021/np7007494

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Roseophilin is a unique metabolite containing two pyrrole and one furan ring and is structurally related to tripyrrole antibiotics, prodigiosins. Each homologous gene in the roseophilin producer Streptomyces griseoviridis was amplified by PCR using primers designed from the prodigiosin-biosynthesis genes redH, redM, and redW. A search for prodigiosins produced by S. griseoviridis resulted in the isolation of a new prodigiosin designated prodigiosin R1 (1). The molecular formula of 1 was established as C27H37N30 by high-resolution FABMS. The structure of 1 was elucidated by NMR spectroscopic analysis including COSY, HMQC, HMBC, and NOESY. Prodigiosin R1 (1) is a new member of the prodigiosin family possessing a cyclic alkyl side chain.

引用

页码：1265 / 1267

页数：3

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