Knockout of the Sendai virus C gene eliminates the viral ability to prevent the interferon-α/β-mediated responses

被引：116

作者：

Gotoh, B

Takeuchi, K

Komatsu, T

Yokoo, J

Kimura, Y

Kurotani, A

Kato, A

Nagai, Y

机构：

[1] Fukui Med Univ, Dept Microbiol, Fukui 9101193, Japan

[2] Fukui Med Univ, Radioisotope Res Inst, Fukui 9101193, Japan

[3] Natl Inst Infect Dis, Dept Viral Dis & Vaccine Control, Tokyo 2080011, Japan

[4] Univ Tokyo, Inst Med Sci, Dept Viral Infect, Minato Ku, Tokyo 1088639, Japan

[5] Natl Inst Infect Dis, AIDS Res Ctr, Shinjuku Ku, Tokyo 1628640, Japan

来源：

FEBS LETTERS | 1999年 / 459卷 / 02期

关键词：

Sendai virus; C protein; interferon; interferon-stimulated gene; Stat1; p48;

D O I：

10.1016/S0014-5793(99)01241-7

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Sendai virus (SeV) renders cells unresponsive to interferon (IFN)-alpha. To identify viral factors involved in this process, we examined whether recombinant SeVs, which could not express V protein, subsets of C proteins (C, C', Y1 and Y2) or any of four C proteins, retained the capability of impeding IFN-a-mediated responses. Among these viruses, only the 4C knockout virus completely lost the ability to suppress the induction of IFN-alpha-stimulated gene products and the subsequent establishment of an anti-viral state. These findings reveal crucial roles of the SeV C proteins in blocking IFN-alpha-mediated responses. (C) 1999 Federation of European Biochemical Societies.

引用

页码：205 / 210

页数：6

共 44 条

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