Knockout of the Sendai virus C gene eliminates the viral ability to prevent the interferon-α/β-mediated responses

被引：116
作者：
Gotoh, B
Takeuchi, K
Komatsu, T
Yokoo, J
Kimura, Y
Kurotani, A
Kato, A
Nagai, Y
机构：
[1] Fukui Med Univ, Dept Microbiol, Fukui 9101193, Japan
[2] Fukui Med Univ, Radioisotope Res Inst, Fukui 9101193, Japan
[3] Natl Inst Infect Dis, Dept Viral Dis & Vaccine Control, Tokyo 2080011, Japan
[4] Univ Tokyo, Inst Med Sci, Dept Viral Infect, Minato Ku, Tokyo 1088639, Japan
[5] Natl Inst Infect Dis, AIDS Res Ctr, Shinjuku Ku, Tokyo 1628640, Japan
来源：
FEBS LETTERS | 1999年 / 459卷 / 02期
关键词：
Sendai virus; C protein; interferon; interferon-stimulated gene; Stat1; p48;
D O I：
10.1016/S0014-5793(99)01241-7
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Sendai virus (SeV) renders cells unresponsive to interferon (IFN)-alpha. To identify viral factors involved in this process, we examined whether recombinant SeVs, which could not express V protein, subsets of C proteins (C, C', Y1 and Y2) or any of four C proteins, retained the capability of impeding IFN-a-mediated responses. Among these viruses, only the 4C knockout virus completely lost the ability to suppress the induction of IFN-alpha-stimulated gene products and the subsequent establishment of an anti-viral state. These findings reveal crucial roles of the SeV C proteins in blocking IFN-alpha-mediated responses. (C) 1999 Federation of European Biochemical Societies.
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页码：205 / 210
页数：6
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