Determination of acyclovir in human plasma by high-performance liquid chromatography

被引：57

作者：

Boulieu, R ^{[1
]}

Gallant, C ^{[1
]}

Silberstein, N ^{[1
]}

机构：

[1] HOP NEUROCARDIOL,SERV PHARMACEUT,F-69394 LYON 03,FRANCE

来源：

JOURNAL OF CHROMATOGRAPHY B | 1997年 / 693卷 / 01期

关键词：

acyclovir;

D O I：

10.1016/S0378-4347(97)00037-6

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

A selective and sensitive isocratic high-performance liquid chromatographic method for the analysis of acyclovir in human plasma was described. Acid deproteinisation was used as sample treatment. Mean analytical recoveries were higher than 94% at low and high concentrations, The quantification limit was 0.1 mg/l for a plasma volume of 500 mu l and precision study exhibits coefficients of variation lower than 5%. The method is suitable for therapeutic monitoring of acyclovir concentrations in organ-transplant recipients.

引用

页码：233 / 236

页数：4

共 50 条

[31] Rapid determination of antiviral medication ribavirin in different feedstuffs using a novel magnetic molecularly imprinted polymer coupled with high-performance liquid chromatography [J].

Ma, Jin-Kui ;

Huang, Xiao-Chen ;

Wei, Shou-Lian .

JOURNAL OF SEPARATION SCIENCE, 2019, 42 (21) :3372-3381

[32] A New Electrochemical Method for Simultaneous Determination of Acyclovir and Methotrexate in Pharmaceutical and Human Plasma Samples [J].

Saleh, Gamal A. ;

Askal, Hassan F. ;

Refaat, Ibrahim H. ;

Abdel-aal, Fatma A. M. .

ANALYTICAL & BIOANALYTICAL ELECTROCHEMISTRY, 2016, 8 (06) :691-716

[33] A metabolic profiling analysis of the nephrotoxicity of acyclovir in rats using ultra performance liquid chromatography/mass spectrometry [J].

Xing, Wenmin ;

Gu, Lili ;

Zhang, Xinyue ;

Xu, Jiadong ;

Lu, Hong .

ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY, 2016, 46 :234-240

[34] Quantitative determination of acyclovir in plasma by near infrared spectroscopy [J].

Yu, Liyan ;

Xiang, Bingren .

MICROCHEMICAL JOURNAL, 2008, 90 (01) :63-66

[35] Rapid determination of acyclovir in plasma and cerebrospinal fluid by micellar electrokinetic chromatography with direct sample injection and its clinical application [J].

Yeh, HH ;

Yang, YH ;

Chen, SH .

ELECTROPHORESIS, 2006, 27 (04) :819-826

[36] Measurement of ganciclovir concentration in human plasma by ultra-performance liquid chromatography-tandem mass spectrometry [J].

Rigo-Bonnin, Rauel ;

Padulles, Ariadna ;

Corral-Comesana, Sofia ;

Cerezo, Gema ;

Maria Grinyo, Josep ;

Colom, Helena ;

Alia-Ramos, Pedro ;

Lloberas, Nuria .

CLINICA CHIMICA ACTA, 2014, 427 :58-64

[37] Determination of acyclovir (zovirax) and guanine by microbore highperformance liquid chromatography with confirmation by atmospheric-pressure chemical ionization mass spectrometry [J].

KouranyLefoll, E ;

Cyr, TD .

CANADIAN JOURNAL OF APPLIED SPECTROSCOPY, 1995, 40 (06) :155-159

[38] Determination of penciclovir in human plasma by liquid chromatography-electrospray ionization tandem mass spectrometry: application to a clinical pharmacokinetic study [J].

Kanneti, Ravi ;

Bhavesh, Dasandi ;

Paramar, Dharmesh ;

Shivaprakash, R. ;

Bhatt, Parloop A. .

BIOMEDICAL CHROMATOGRAPHY, 2011, 25 (04) :458-465

[39] Determination of acyclovir in dog plasma by HPLC using a column switching technique [J].

K. Balogh Nemes ;

B. Dalmadi Kiss ;

I. Klebovich .

Chromatographia, 2000, 51 :S211-S216

[40] Determination of acyclovir in dog plasma by HPLC using a column switching technique [J].

Nemes, KB ;

Kiss, BD ;

Klebovich, I .

CHROMATOGRAPHIA, 2000, 51 (1) :S211-S216

← 1 2 3 4 5 →