Determination of acyclovir in human plasma by high-performance liquid chromatography

被引：57
|
作者：
Boulieu, R [1 ]
Gallant, C [1 ]
Silberstein, N [1 ]
机构：
[1] HOP NEUROCARDIOL,SERV PHARMACEUT,F-69394 LYON 03,FRANCE
来源：
JOURNAL OF CHROMATOGRAPHY B | 1997年 / 693卷 / 01期
关键词：
acyclovir;
D O I：
10.1016/S0378-4347(97)00037-6
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
A selective and sensitive isocratic high-performance liquid chromatographic method for the analysis of acyclovir in human plasma was described. Acid deproteinisation was used as sample treatment. Mean analytical recoveries were higher than 94% at low and high concentrations, The quantification limit was 0.1 mg/l for a plasma volume of 500 mu l and precision study exhibits coefficients of variation lower than 5%. The method is suitable for therapeutic monitoring of acyclovir concentrations in organ-transplant recipients.
引用
收藏
页码：233 / 236
页数：4
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