The tumor microenvironment of colorectal cancer metastases: opportunities in cancer immunotherapy

被引：40

作者：

Kamal, Yasmin ^{[1
,2
]}

Schmit, Stephanie L. ^{[3
]}

Frost, Hildreth Robert ^{[1
,2
]}

Amos, Christopher, I ^{[1
,2
,4
]}

机构：

[1] Geisel Sch Med Dartmouth, Dept Biomed Data Sci, Hanover, NH 03755 USA

[2] Geisel Sch Med Dartmouth, Quantitat Biomed Sci, Hanover, NH 03755 USA

[3] H Lee Moffitt Canc Ctr & Res Inst, Dept Canc Epidmiol, Tampa, FL 33612 USA

[4] Baylor Coll Med, Dan L Duncan Comprehens Canc Ctr, Houston, TX 77030 USA

来源：

IMMUNOTHERAPY | 2020年 / 12卷 / 14期

关键词：

bi-specific T-cell engagers; CAR-T-cell therapy; colorectal cancer; dendritic cell vaccine; immune checkpoint inhibitors; immune microenvironment; liver metastases; metastasis; microsatellite instability; Toll-like receptor agonists; EPITHELIAL-MESENCHYMAL TRANSITION; DENDRITIC CELL VACCINATION; MISMATCH REPAIR-DEFICIENT; MICROSATELLITE INSTABILITY; COLON-CANCER; T-CELLS; LIVER METASTASIS; PD-1; BLOCKADE; FUSOBACTERIUM-NUCLEATUM; ACQUIRED-RESISTANCE;

D O I：

10.2217/imt-2020-0026

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

About a fifth of individuals with colorectal cancer (CRC) present with disease metastasis at the time of diagnosis. While the role of the tumor microenvironment (TME) in governing CRC progression is undeniable, the role of the TME in either establishing or suppressing the formation of distant metastases of CRC is less well established. Despite advances in immunotherapy, many individuals with metastatic CRC do not respond to standard-of-care therapy. Therefore, understanding the role of the TME in establishing distant metastases is essential for developing new immunological agents. Here, we summarize our current understanding of the TME of CRC metastases, describe differences between the TME of primary tumors and their distant metastases, and discuss advances in the design and combinations of immunotherapeutic agents.

引用

页码：1083 / 1100

页数：18

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