Nephrotoxicity of methadone: a systematic review

被引：20
作者：
Alinejad, Samira [1 ]
Ghaemi, Kazem [2 ,3 ]
Abdollahi, Mohammad [4 ]
Mehrpour, Omid [1 ]
机构：
[1] Birjand Univ Med Sci, Med Toxicol & Drug Abuse Res Ctr MTDRC, Moallem Ave, Birjand 9713643138, Iran
[2] Birjand Univ Med Sci, Atherosclerosis & Coronary Artery Res Ctr, Birjand, Iran
[3] Birjand Univ Med Sci, Dept Neurosurg, Birjand, Iran
[4] Univ Tehran Med Sci, Pharmaceut Sci Res Ctr, Toxicol & Dis Grp, Tehran, Iran
来源：
SPRINGERPLUS | 2016年 / 5卷
关键词：
Methadone; Kidney; Renal; Toxicity; Rhabdomyolysis; ACUTE-RENAL-FAILURE; INTRAVENOUS-DRUG-USERS; KIDNEY-TRANSPLANTATION; INDUCED RHABDOMYOLYSIS; AA-AMYLOIDOSIS; ABUSE; PHARMACOLOGY; DIAGNOSIS; OVERDOSE; PATHOPHYSIOLOGY;
D O I：
10.1186/s40064-016-3757-1
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Background: Methadone is commonly administered for chronic pain relief and treatment of opioid dependence. Concurrent with its increased consumption, toxicities and fatalities have increased. One of the adverse effects of opioid analgesics, including methadone, is that of nephrotoxicity. Opioids can have an effect on renal function through several different mechanisms. Methods: We searched common bibliographical databases for the terms methadone, toxicity, poisoning, kidney, renal, and nephrotoxicity and summarize our findings in this review. Results: Methadone can have both direct and indirect effects on the kidney. These effects include rhabdomyolysis (leading to acute kidney injury), volumetric changes, renal lipidosis and amyloidosis, kidney growth during pregnancy, and kidney transplant rejection. Conclusion: Improved understanding of the effects of methadone on kidney function can promote safer and more confident use of the drug.
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页数：9
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