POST-REASSORTMENT AMINO ACID CHANGE IN THE HEMAGGLUTININ OF A HUMAN-AVIAN INFLUENZA H5N1 REASSORTANT VIRUS ALTERS ITS ANTIGENIC SPECIFICITY

被引：0
作者：
Rudneva, I. A. [1 ]
Timofeeva, T. A. [1 ]
Ilyushina, N. A. [1 ,2 ]
Varich, N. L. [1 ]
Kochergin-Nikitsky, K. S. [1 ]
Kaverin, N. V. [1 ]
机构：
[1] Russian Acad Med Sci, DI Ivanovskii Virol Inst, Moscow 123098, Russia
[2] St Jude Childrens Res Hosp, Dept Infect Dis, Memphis, TN 38105 USA
来源：
ACTA VIROLOGICA | 2008年 / 52卷 / 03期
基金：
俄罗斯基础研究基金会;
关键词：
influenza virus; reassortment; amino acid change; antigenic specificity;
D O I：
暂无
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
it was shown earlier that the reassortant influenza virus having hemagglutinin (HA) gene of A/Duck/Primorie/2621/2001 (H5N2) virus and 7 genes of A/Puerto Rico/8/34 (H1N1) virus produced low yields in embryonated chicken eggs. We found that a variant reassortant selected by serial passages in eggs produced higher yields than the initial reassortant. The variant reassortant had an amino acid substitution in the hemagglutinin N244D (H3 numbering). In this report we demonstrated that the post-reassortment amino acid substitution N244D altered the antigenic specificity of HA as revealed by the loss of reactivity with all anti-H5 monoclonal antibody in hemagglutination-inhibition (HI) test. The results are discussed in association with the evolution of H5 hemagglutinin.
引用
收藏
页码：181 / 184
页数：4
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