Asymmetric synthesis of beta-amino acids and alpha-substituted beta-amino acids

被引:572
作者
Cardillo, G
Tomasini, C
机构
关键词
D O I
10.1039/cs9962500117
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
beta-Amino acids are present in a wide variety of biologically active natural products and are constituents of the beta-lactam framework. The first part of this review is intended to report some relevant naturally occurring compounds containing beta-amino acids. The second part summarises some of the more recent developments in the synthesis of beta-amino acids and alpha-substituted beta-amino acids, by routes involving the enzymatic resolution of racemic mixtures, the intermediary preparation of perhydropyrimidin-4-ones and the conjugate addition of ammonia equivalents to alpha,beta-unsaturated esters and imides.
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页码:117 / &
页数:13
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