Innate immune activation in obesity

被引：108
|
作者：
Lumeng, Carey N. [1 ,2 ]
机构：
[1] Univ Michigan, Sch Med, Dept Pediat & Communicable Dis, Ann Arbor, MI USA
[2] Univ Michigan, Sch Med, Ann Arbor, MI USA
来源：
MOLECULAR ASPECTS OF MEDICINE | 2013年 / 34卷 / 01期
基金：
美国国家卫生研究院;
关键词：
Obesity; Inflammation; Macrophages; Type; 2; diabetes; Insulin resistance; Metabolic syndrome; ADIPOSE-TISSUE MACROPHAGES; ACYLATION-STIMULATING PROTEIN; MONOCYTE CHEMOATTRACTANT PROTEIN-1; INDUCED INSULIN-RESISTANCE; NECROSIS-FACTOR-ALPHA; TOLL-LIKE RECEPTOR-4; DIET-INDUCED OBESITY; KILLER T-CELLS; NF-KAPPA-B; METABOLIC SYNDROME;
D O I：
10.1016/j.mam.2012.10.002
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The innate immune system is a prewired set of cellular and humoral components that has developed to sense perturbations in normal physiology and trigger responses to restore the system back to baseline. It is now understood that many of these components can also sense the physiologic changes that occur with obesity and be activated. While the exact reasons for this chronic immune response to obesity are unclear, there is strong evidence to suggest that innate inflammatory systems link obesity and disease. Based on this, anti-inflammatory therapies for diseases like type 2 diabetes and metabolic syndrome may form the core of future treatment plans. This review will highlight the components involved in the innate immune response and discuss the evidence that they contribute to the pathogenesis of obesity-associated diseases. (C) 2012 Published by Elsevier Ltd.
引用
收藏
页码：12 / 29
页数：18
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