Navigation and analysis of the energy landscape of small proteins using the activation-relaxation technique

被引：6
|
作者：
Mousseau, N
Derreumaux, P
Gilbert, G
机构：
[1] Univ Montreal, Dept Phys, Montreal, PQ H3C 3J7, Canada
[2] Univ Montreal, Regroupement Quebecois Mat Pointe, Montreal, PQ H3C 3J7, Canada
[3] Inst Biol Physicochim, CNRS, UPR 9080, Lab Biochim Theor, F-75005 Paris, France
[4] Univ Paris 07, F-75005 Paris, France
来源：
PHYSICAL BIOLOGY | 2005年 / 2卷 / 04期
关键词：
FINDING SADDLE-POINTS; PEPTIDE; DYNAMICS; SIMULATIONS; TOPOLOGY;
D O I：
10.1088/1478-3975/2/4/S04
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The resolution of the protein folding problem has been tied to the development of a detailed understanding of the configurational energy or of the free energy landscape associated with these molecules. Using the activation-relaxation technique and a simplified energy model, we present here a detailed analysis of the energy landscape of 16-residue peptide that folds into a beta-hairpin. Our results support the concept of an energy landscape with an effective topology consistent with a scale-free network.
引用
收藏
页码：S101 / S107
页数：7
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