Fucoxanthin prevents lipopolysaccharide-induced depressive-like behavior in mice via AMPK- NF-B pathway

被引:49
作者
Jiang, Xi [1 ,2 ]
Wang, Guokang [1 ]
Lin, Qian [3 ]
Tang, Zhihua [4 ]
Yan, Qizhi [4 ]
Yu, Xuefeng [1 ]
机构
[1] Zhejiang Pharmaceut Coll, Inst Pharmacol & Toxicol, Dept Pharm, Ningbo 315000, Zhejiang, Peoples R China
[2] Ningbo Mingzhou Hosp, Ningbo 315000, Zhejiang, Peoples R China
[3] Univ Louisville, Dept Pharmacol & Toxicol, Louisville, KY 40202 USA
[4] Zhejiang Univ, Sch Med, Shaoxing Hosp, Shaoxing Peoples Hosp, Shaoxing 312000, Peoples R China
关键词
Fucoxanthin; Lipopolysaccharide (LPS); Depression; Inflammation; AMPK; NF-kappa B; DIET-INDUCED OBESITY; KAPPA-B; RAT MODEL; FAT; INFLAMMATION; ACTIVATION; REACTIVITY; SYSTEM;
D O I
10.1007/s11011-018-0368-2
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Fucoxanthin (FX), a natural carotenoid abundant in edible brown seaweeds, has been shown the great anti-oxidant, anti-inflammatory and anti-diabetic effects in vivo and in vitro. The present study was designed to investigate the effects of FX on lipopolysaccharide (LPS)-induced behavioral defects in mice. In depressive behavior tests, the increased immobility time of forced swimming test and tail suspension test by LPS treatment in mice, which were significantly reversed by FX treatment (200mg/kg, i.g.). In anxiety behavior tests, LPS injection was neither influence the anxiety-related parameters in marble burying test nor that in elevated plus maze test. Interestingly, anxiolytic effects were observed in single FX treated control and LPS-induced mice groups. FX treatment also reversed LPS-induced body weight loss and food intake decreases. Biochemical analysis indicated that FX inhibited LPS-induced overexpression of pro-inflammatory cytokines (IL-1, IL-6 and TNF-), as well as iNOS and COX-2 in the hippocampus, frontal cortex and hypothalamus, via the modulation of AMPK-NF-B signaling pathway.
引用
收藏
页码:431 / 442
页数:12
相关论文
共 36 条
[1]   AMPK agonist downregulates innate and adaptive immune responses in TNBS-induced murine acute and relapsing colitis [J].
Bai, Aiping ;
Ma, Allan G. ;
Yong, Michael ;
Weiss, Carolyn R. ;
Ma, Yanbing ;
Guan, Qingdong ;
Bernstein, Charles N. ;
Peng, Zhikang .
BIOCHEMICAL PHARMACOLOGY, 2010, 80 (11) :1708-1717
[2]   Fucoxanthin attenuates fatty acid-induced lipid accumulation in FL83B hepatocytes through regulated Sirt1/AMPK signaling pathway [J].
Chang, Yi-Hsien ;
Chen, Ya-Ling ;
Huang, Wen-Chung ;
Liou, Chian-Jiun .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2018, 495 (01) :197-203
[3]   Synergistic chondroprotective effects of curcumin and resveratrol in human articular chondrocytes: inhibition of IL-1β-induced NF-κB-mediated inflammation and apoptosis [J].
Csaki, Constanze ;
Mobasheri, Ali ;
Shakibaei, Mehdi .
ARTHRITIS RESEARCH & THERAPY, 2009, 11 (06)
[4]   From inflammation to sickness and depression: when the immune system subjugates the brain [J].
Dantzer, Robert ;
O'Connor, Jason C. ;
Freund, Gregory G. ;
Johnson, Rodney W. ;
Kelley, Keith W. .
NATURE REVIEWS NEUROSCIENCE, 2008, 9 (01) :46-57
[5]   5-aminoimidazole-4-carboxamide-1-β-4-ribofuranoside inhibits proinflammatory response in glial cells:: A possible role of AMP-activated protein kinase [J].
Giri, S ;
Nath, N ;
Smith, B ;
Viollet, B ;
Singh, AK ;
Singh, I .
JOURNAL OF NEUROSCIENCE, 2004, 24 (02) :479-487
[6]   Chronic intermittent cold stress sensitizes neuro-immune reactivity in the rat brain [J].
Girotti, Milena ;
Donegan, Jennifer J. ;
Morilak, David A. .
PSYCHONEUROENDOCRINOLOGY, 2011, 36 (08) :1164-1174
[7]  
Hayley S, 1999, J NEUROSCI, V19, P5654
[8]   Proanthocyanidin prevents lipopolysaccharide-induced depressive-like behavior in mice via neuroinflammatory pathway [J].
Jiang, Xi ;
Liu, Ji ;
Lin, Qian ;
Mao, Kaili ;
Tian, Furong ;
Jing, Changfeng ;
Wang, Chongbin ;
Ding, Lianshu ;
Pang, Cong .
BRAIN RESEARCH BULLETIN, 2017, 135 :40-46
[9]   Trans-astaxanthin attenuates lipopolysaccharide-induced neuroinflammation and depressive-like behavior in mice [J].
Jiang, Xi ;
Chen, Lei ;
Shen, Lailai ;
Chen, Ziwei ;
Xu, Lexing ;
Zhang, Jiajia ;
Yu, Xuefeng .
BRAIN RESEARCH, 2016, 1649 :30-37
[10]   Overt Irritability/Anger in Unipolar Major Depressive Episodes Past and Current Characteristics and Implications for Long-term Course [J].
Judd, Lewis L. ;
Schettler, Pamela J. ;
Coryell, William ;
Akiskal, Hagop S. ;
Fiedorowicz, Jess G. .
JAMA PSYCHIATRY, 2013, 70 (11) :1171-1180