The genetic pathogenesis, diagnosis and therapeutic insight of rheumatoid arthritis

被引：45

作者：

Zamanpoor, Mansour ^{[1
,2
]}

机构：

[1] Univ Otago, Dept Biochem, Dunedin, New Zealand

[2] Wellington Reg Hosp, Genet Hlth Serv New Zealand, Wellington Reg Genet Lab, Private Bag 7902, Wellington 6242, New Zealand

来源：

CLINICAL GENETICS | 2019年 / 95卷 / 05期

关键词：

Rheumatoid Arthritis; Genetic; Pathogenesis; GWAS; HLA; GENOME-WIDE ASSOCIATION; TYROSINE-PHOSPHATASE PTPN22; VITAMIN-D; SHARED EPITOPE; CITRULLINATED PEPTIDE; FC RECEPTOR-LIKE-3; JAPANESE PATIENTS; INCREASED RISK; STAT4; GENE; T-CELLS;

D O I：

10.1111/cge.13498

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Rheumatoid arthritis (RA) is a systemic autoimmune disease that causes chronic inflammation of the joints. RA is a heterogeneous disorder caused by an abnormal autoimmune response triggered by the complex interactions of genetic and environmental factors that contribute to RA etiology. However, its underlying pathogenic mechanisms are yet to be fully understood. In this review, I provide an overview of the pathogenesis, diagnosis and therapeutic insight in the clinical management of RA in light of the recent updates to classification criteria and recent discoveries of genetic loci associated with susceptibility for RA.

引用

页码：547 / 557

页数：11

共 133 条

[1] Distinctions Between Diagnostic and Classification Criteria? [J].

Aggarwal, Rohit ;

Ringold, Sarah ;

Khanna, Dinesh ;

Neogi, Tuhina ;

Johnson, Sindhu R. ;

Miller, Amy ;

Brunner, Hermine I. ;

Ogawa, Rikke ;

Felson, David ;

Ogdie, Alexis ;

Aletaha, Daniel ;

Feldman, Brian M. .

ARTHRITIS CARE & RESEARCH, 2015, 67 (07) :891-897

[2] Diagnosis and Management of Rheumatoid Arthritis A Review [J].

Aletaha, Daniel ;

Smolen, Josef S. .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2018, 320 (13) :1360-1372

[3] 2010 Rheumatoid Arthritis Classification Criteria An American College of Rheumatology/European League Against Rheumatism Collaborative Initiative [J].

Aletaha, Daniel ;

Neogi, Tuhina ;

Silman, Alan J. ;

Funovits, Julia ;

Felson, David T. ;

Bingham, Clifton O., III ;

Birnbaum, Neal S. ;

Burmester, Gerd R. ;

Bykerk, Vivian P. ;

Cohen, Marc D. ;

Combe, Bernard ;

Costenbader, Karen H. ;

Dougados, Maxime ;

Emery, Paul ;

Ferraccioli, Gianfranco ;

Hazes, Johanna M. W. ;

Hobbs, Kathryn ;

Huizinga, Tom W. J. ;

Kavanaugh, Arthur ;

Kay, Jonathan ;

Kvien, Tore K. ;

Laing, Timothy ;

Mease, Philip ;

Menard, Henri A. ;

Moreland, Larry W. ;

Naden, Raymond L. ;

Pincus, Theodore ;

Smolen, Josef S. ;

Stanislawska-Biernat, Ewa ;

Symmons, Deborah ;

Tak, Paul P. ;

Upchurch, Katherine S. ;

Vencovsky, Jiri ;

Wolfe, Frederick ;

Hawker, Gillian .

ARTHRITIS AND RHEUMATISM, 2010, 62 (09) :2569-2581

[4] Foxp3+ Helios+ regulatory T cells are expanded in active systemic lupus erythematosus [J].

Alexander, Tobias ;

Sattler, Arne ;

Templin, Lars ;

Kohler, Siegfried ;

Gross, Christian ;

Meisel, Andreas ;

Sawitzki, Birgit ;

Burmester, Gerd-Ruediger ;

Arnold, Renate ;

Radbruch, Andreas ;

Thiel, Andreas ;

Hiepe, Falk .

ANNALS OF THE RHEUMATIC DISEASES, 2013, 72 (09) :1549-1558

[5] Driving chronicity in rheumatoid arthritis: perpetuating role of myeloid cells [J].

Alivernini, S. ;

Tolusso, B. ;

Ferraccioli, G. ;

Gremese, E. ;

Kurowska-Stolarska, M. ;

McInnes, I. B. .

CLINICAL AND EXPERIMENTAL IMMUNOLOGY, 2018, 193 (01) :13-23

[6] Synovial cellular and molecular markers in rheumatoid arthritis [J].

Amin, M. Asif ;

Fox, David A. ;

Ruth, Jeffrey H. .

SEMINARS IN IMMUNOPATHOLOGY, 2017, 39 (04) :385-393

[7]

Anzilotti C, 2006, J RHEUMATOL, V33, P647

[8] THE AMERICAN-RHEUMATISM-ASSOCIATION 1987 REVISED CRITERIA FOR THE CLASSIFICATION OF RHEUMATOID-ARTHRITIS [J].

ARNETT, FC ;

EDWORTHY, SM ;

BLOCH, DA ;

MCSHANE, DJ ;

FRIES, JF ;

COOPER, NS ;

HEALEY, LA ;

KAPLAN, SR ;

LIANG, MH ;

LUTHRA, HS ;

MEDSGER, TA ;

MITCHELL, DM ;

NEUSTADT, DH ;

PINALS, RS ;

SCHALLER, JG ;

SHARP, JT ;

WILDER, RL ;

HUNDER, GG .

ARTHRITIS AND RHEUMATISM, 1988, 31 (03) :315-324

[9] A function for the QKRAA amino acid motif: Mediating binding of DnaJ to DnaK - Implications for the association of rheumatoid arthritis with HLA-DR4 [J].

Auger, I ;

Roudier, J .

JOURNAL OF CLINICAL INVESTIGATION, 1997, 99 (08) :1818-1822

[10] Epstein-Barr virus and rheumatoid arthritis [J].

Balandraud, N ;

Roudier, J ;

Roudier, C .

AUTOIMMUNITY REVIEWS, 2004, 3 (05) :362-367

← 1 2 3 4 5 6 7 8 9 10 →