Expression of c-Fos after noise-induced temporary threshold shift in the guinea pig cochlea

被引：31

作者：

Shizuki, K

Ogawa, K

Matsunobu, T

Kanzaki, J

Ogita, K

机构：

[1] Natl Tokyo Med Ctr, Dept Otolaryngol, Meguro Ku, Tokyo 1528902, Japan

[2] Keio Univ, Sch Med, Dept Otolaryngol, Shinjuku Ku, Tokyo 1600016, Japan

[3] Kitasato Inst Hosp, Dept Otolaryngol, Minato Ku, Tokyo 1088642, Japan

[4] Setsunan Univ, Dept Pharmacol, Hirakata, Osaka 5730101, Japan

来源：

NEUROSCIENCE LETTERS | 2002年 / 320卷 / 1-2期

关键词：

c-Fos; activator protein-1; temporary threshold shift; noise; hearing loss; cochlea; oxidative stress;

D O I：

10.1016/S0304-3940(02)00059-9

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

c-Fos is known to be a component of a transcription factor, activator protein-1, which is induced by oxidative stress. Guinea pigs were exposed to 4 kHz band noise of 110 dB SPL for 1 or 5 h and the expression of c-Fos in the organ of Corti was determined using Western blotting analysis and immunocytochemistry. c-Fos was expressed only after the noise exposure. The c-Fos expression was mainly found in the Hensen's cells, Claudius' cells and Deiter's cells of the basal and second turns of the cochlea. Since the threshold shift was temporary, the expression of c-Fos is therefore considered to contribute to the survival or protective function of the organ of Corti. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：73 / 76

页数：4

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