Secondary metabolites from the root of Ehretia longiflora and their biological activities

被引：22
|
作者：
Chien, Yu-Chieh [1 ]
Lin, Chu-Hung [2 ]
Chiang, Michael Y. [3 ]
Chang, Hsun-Shuo [1 ]
Liao, Chang-Hui [4 ]
Chen, Ih-Sheng [1 ,2 ]
Peng, Chien-Fang [5 ]
Tsai, Ian-Lih [1 ,2 ]
机构：
[1] Kaohsiung Med Univ, Coll Pharm, Grad Inst Nat Prod, Kaohsiung 807, Taiwan
[2] Kaohsiung Med Univ, Coll Pharm, Sch Pharm, Kaohsiung 807, Taiwan
[3] Natl Sun Yat Sen Univ, Dept Chem, Kaohsiung 804, Taiwan
[4] Chang Gung Univ, Coll Med, Grad Inst Nat Prod, Tao Yuan 333, Taiwan
[5] Kaohsiung Med Univ, Coll Hlth Sci, Dept Med Lab Sci & Biotechnol, Kaohsiung 807, Taiwan
来源：
PHYTOCHEMISTRY | 2012年 / 80卷
关键词：
Ehretia longiflora; Boraginaceae; Root; Antitubercular activity; Anti-inflammatory activity; ACID; GRANULOCYTES; CONSTITUENTS; GLUCOSIDES; LEUKOCYTES; COMPOUND; BLOOD; CELLS;
D O I：
10.1016/j.phytochem.2012.04.013
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Bioassay-guided fractionation of the methanolic extract of the root of Ehretia longiflora (Boraginaceae) afforded eight compounds. ehretiquinone (1), ehretiolide (2), ehreticoumarin (3), ehretilactone A (4), ehretilactone B (5), ehretiamide (6), ehretine (7), and ehretiate (8), together with 12 known compounds (9-20). The relative configuration of 1 was determined by single crystal X-ray diffraction. Among the isolates, 1 and prenylhydroquinone (14) showed antitubercular activity against Mycobacterium tuberculosis strain H37Rv with MIC values of 25.0 and 26.2 mu g/mL, respectively. Moreover, 1 exhibited inhibitory effects on N-formylmethionylleucylphenylalanine (fMLP)-induced superoxide production, with IC50 value of 0.36 +/- 0.03 mu M. (C) 2012 Elsevier Ltd. All rights reserved.
引用
收藏
页码：50 / 57
页数：8
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