Secondary metabolites from the root of Ehretia longiflora and their biological activities

被引：22

作者：

Chien, Yu-Chieh ^{[1
]}

Lin, Chu-Hung ^{[2
]}

Chiang, Michael Y. ^{[3
]}

Chang, Hsun-Shuo ^{[1
]}

Liao, Chang-Hui ^{[4
]}

Chen, Ih-Sheng ^{[1
,2
]}

Peng, Chien-Fang ^{[5
]}

Tsai, Ian-Lih ^{[1
,2
]}

机构：

[1] Kaohsiung Med Univ, Coll Pharm, Grad Inst Nat Prod, Kaohsiung 807, Taiwan

[2] Kaohsiung Med Univ, Coll Pharm, Sch Pharm, Kaohsiung 807, Taiwan

[3] Natl Sun Yat Sen Univ, Dept Chem, Kaohsiung 804, Taiwan

[4] Chang Gung Univ, Coll Med, Grad Inst Nat Prod, Tao Yuan 333, Taiwan

[5] Kaohsiung Med Univ, Coll Hlth Sci, Dept Med Lab Sci & Biotechnol, Kaohsiung 807, Taiwan

来源：

PHYTOCHEMISTRY | 2012年 / 80卷

关键词：

Ehretia longiflora; Boraginaceae; Root; Antitubercular activity; Anti-inflammatory activity; ACID; GRANULOCYTES; CONSTITUENTS; GLUCOSIDES; LEUKOCYTES; COMPOUND; BLOOD; CELLS;

D O I：

10.1016/j.phytochem.2012.04.013

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Bioassay-guided fractionation of the methanolic extract of the root of Ehretia longiflora (Boraginaceae) afforded eight compounds. ehretiquinone (1), ehretiolide (2), ehreticoumarin (3), ehretilactone A (4), ehretilactone B (5), ehretiamide (6), ehretine (7), and ehretiate (8), together with 12 known compounds (9-20). The relative configuration of 1 was determined by single crystal X-ray diffraction. Among the isolates, 1 and prenylhydroquinone (14) showed antitubercular activity against Mycobacterium tuberculosis strain H37Rv with MIC values of 25.0 and 26.2 mu g/mL, respectively. Moreover, 1 exhibited inhibitory effects on N-formylmethionylleucylphenylalanine (fMLP)-induced superoxide production, with IC50 value of 0.36 +/- 0.03 mu M. (C) 2012 Elsevier Ltd. All rights reserved.

引用

页码：50 / 57

页数：8

共 41 条

[1] HYDROXY-(METHYLBUTENYNYL)-BENZOIC ACID AND DERIVATIVES FROM CURVULARIA-FALLAX
ABRAHAM, WR
ARFMANN, HA
[J]. PHYTOCHEMISTRY, 1990, 29 (08) : 2641 - 2644
[2] Acremine G, dimeric metabolite from cultures of Acremonium byssoides A20
Arnone, Alberto
Nasini, Gianluca
Panzeri, Walter
de Pava, Orso Vajna
Malpezzi, Luciana
[J]. JOURNAL OF NATURAL PRODUCTS, 2008, 71 (01): : 146 - 149
[3] BIOLOGICAL DEFENSE MECHANISMS - PRODUCTION BY LEUKOCYTES OF SUPEROXIDE A POTENTIAL BACTERICIDAL AGENT
BABIOR, BM
KIPNES, RS
CURNUTTE, JT
[J]. JOURNAL OF CLINICAL INVESTIGATION, 1973, 52 (03) : 741 - 744
[4] Antioxidant properties of 3-hydroxycoumarin derivatives
Bailly, F
Maurin, C
Teissier, E
Vezin, H
Cotelle, P
[J]. BIOORGANIC & MEDICINAL CHEMISTRY, 2004, 12 (21) : 5611 - 5618
[5] BOYUM A, 1968, SCAND J CLIN LAB INV, VS 21, P77
[6] Structural changes of sinapic acid and sinapine bisulfate during autoclaving with respect to the development of colored substances
Cai, R
Arntfield, SD
Charlton, JL
[J]. JOURNAL OF THE AMERICAN OIL CHEMISTS SOCIETY, 1999, 76 (04) : 433 - 441
[7] SWERTANE TRITERPENOIDS FROM SWERTIA-CHIRATA
CHAKRAVARTY, AK
MUKHOPADHYAY, S
DAS, B
[J]. PHYTOCHEMISTRY, 1991, 30 (12) : 4087 - 4092
[8] ANNELATED FURANS .17. WITTIG REACTION OF BENZOFURANONES
CHAN, JHT
ELIX, JA
FERGUSON, BA
[J]. AUSTRALIAN JOURNAL OF CHEMISTRY, 1975, 28 (05) : 1097 - 1111
[9] SYNTHESIS AND ABSOLUTE-CONFIGURATION OF THE NATURALLY-OCCURRING CYANO GLUCOSIDE SIMMONDSIN
CHIDA, N
YAMADA, K
OGAWA, S
[J]. JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1, 1992, (09): : 1131 - 1137
[10] DAN S, 1982, Fitoterapia, V53, P51

← 1 2 3 4 5 →