Reliability of CKD-EPI predictive equation in estimating chronic kidney disease prevalence in the Croatian endemic nephropathy area

被引:3
作者
Fucek, Mirjana [1 ]
Dika, Zivka [2 ]
Karanovic, Sandra [2 ]
Brinar, Ivana Vukovic [2 ]
Premuzic, Vedran [2 ]
Kos, Jelena [2 ]
Cvitkovic, Ante [3 ]
Misic, Maja [4 ]
Samardzic, Josip [4 ]
Rogic, Dunja [1 ]
Jelakovic, Bojan [2 ]
机构
[1] Univ Zagreb, Sch Med, Univ Hosp Ctr Zagreb, Dept Lab Diagnost, Zagreb, Croatia
[2] Univ Zagreb, Sch Med, Univ Hosp Ctr Zagreb, Dept Nephrol Hypertens & Dialysis, Zagreb, Croatia
[3] Brodsko Posavska Cty, Inst Publ Hlth, Slavonski Brod, Croatia
[4] Dr Josip Bencevic Gen Hosp, Dept Pathol, Slavonski Brod, Croatia
关键词
chronic kidney disease; estimated glomerular filtration rate; predictive equation; endemic nephropathy; GLOMERULAR-FILTRATION-RATE;
D O I
10.11613/BM.2018.010701
中图分类号
R446 [实验室诊断]; R-33 [实验医学、医学实验];
学科分类号
1001 ;
摘要
Introduction: Chronic kidney disease (CKD) is a significant public health problem and it is not possible to precisely predict its progression to terminal renal failure. According to current guidelines, CKD stages are classified based on the estimated glomerular filtration rate (eGFR) and albuminuria. Aims of this study were to determine the reliability of predictive equation in estimation of CKD prevalence in Croatian areas with endemic nephropathy (EN), compare the results with non-endemic areas, and to determine if the prevalence of CKD stages 3-5 was increased in subjects with EN. Materials and methods: A total of 1573 inhabitants of the Croatian Posavina rural area from 6 endemic and 3 non-endemic villages were enrolled. Participants were classified according to the modified criteria of the World Health Organization for EN. Estimated GFR was calculated using Chronic Kidney Disease Epidemiology Collaboration equation (CKD-EPI). Results: The results showed a very high CKD prevalence in the Croatian rural area (19%). CKD prevalence was significantly higher in EN then in non EN villages with the lowest eGFR value in diseased subgroup. Conclusions: eGFR correlated significantly with the diagnosis of EN. Kidney function assessment using CKD-EPI predictive equation proved to be a good marker in differentiating the study subgroups, remained as one of the diagnostic criteria for EN.
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页数:8
相关论文
共 20 条
[2]  
[Anonymous], 2013, Kidney Int Suppl, DOI [10.1038/kisup.2012.73, DOI 10.1038/KISUP.2012.73]
[3]  
[Anonymous], B WHO
[4]   Balkan nephropathy: Evolution of our knowledge [J].
Bamias, Giorgos ;
Boletis, John .
AMERICAN JOURNAL OF KIDNEY DISEASES, 2008, 52 (03) :606-616
[5]  
Croatian Bureau of Statistics, CENS POP HOUS DWELL
[6]  
eovic S., 1996, Endemic Nephropathy in Croatia, P7
[7]   Endemic Nephropathy Around the World [J].
Gifford, Fiona J. ;
Gifford, Robert M. ;
Eddleston, Michael ;
Dhaun, Neeraj .
KIDNEY INTERNATIONAL REPORTS, 2017, 2 (02) :282-292
[8]   An Integrated View of Aristolochic Acid Nephropathy: Update of the Literature [J].
Jadot, Ines ;
Decleves, Anne-Emilie ;
Nortier, Joelle ;
Caron, Nathalie .
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2017, 18 (02)
[9]   Renal Medicine 2 Early recognition and prevention of chronic kidney disease [J].
James, Matthew T. ;
Hemmelgarn, Brenda R. ;
Tonelli, Marcello .
LANCET, 2010, 375 (9722) :1296-1309
[10]  
Jelakovic Bojan, 2015, Lijec Vjesn, V137, P100