In vitro testing of combined hydroxychloroquine and azithromycin on SARS-CoV-2 shows synergistic effect

被引：183

作者：

Andreani, Julien ^{[1
,2
]}

Le Bideau, Marion ^{[1
,2
]}

Duflot, Isabelle ^{[1
,2
]}

Jardot, Priscilla ^{[1
,2
]}

Rolland, Clara ^{[1
,2
]}

Boxberger, Manon ^{[1
,2
]}

Wurtz, Nathalie ^{[1
,2
]}

Rolain, Jean-Marc ^{[1
,2
]}

Colson, Philippe ^{[1
,2
]}

La Scola, Bernard ^{[1
,2
]}

Raoult, Didier ^{[1
,2
]}

机构：

[1] IHU Mediterranee Infect, Marseille, France

[2] Aix Marseille Univ, AP HM, MEPHI, IRD, Marseille, France

来源：

MICROBIAL PATHOGENESIS | 2020年 / 145卷

关键词：

2019-nCoV; SARS-CoV-2; COVID-19; Hydroxychloroquine; Azithromycin; Vero E6; RESPIRATORY SYNDROME CORONAVIRUS; Q-FEVER; INFECTION; CHLOROQUINE; CELLS; INHIBITION; DOXYCYCLINE; PNEUMONIA; CHILDREN; DRUG;

D O I：

10.1016/j.micpath.2020.104228

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Human coronaviruses SARS-CoV-2 appeared at the end of 2019 and led to a pandemic with high morbidity and mortality. As there are currently no effective drugs targeting this virus, drug repurposing represents a short-term strategy to treat millions of infected patients at low costs. Hydroxychloroquine showed an antiviral effect in vitro. In vivo it showed efficacy, especially when combined with azithromycin in a preliminary clinical trial. Here we demonstrate that the combination of hydroxychloroquine and azithromycin has a synergistic effect in vitro on SARS-CoV-2 at concentrations compatible with that obtained in human lung.

引用

页数：4

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