Antimicrobial, anti-adhesive and anti-biofilm potential of biosurfactants isolated from Pediococcus acidilactici and Lactobacillus plantarum against Staphylococcus aureus CMCC26003

被引：101
|
作者：
Yan, Xin [1 ,2 ]
Gu, Shanshan [1 ]
Cui, Xingyang [1 ]
Shi, Yunjia [1 ]
Wen, Shanshan [1 ]
Chen, Hongyan [2 ]
Ge, Junwei [1 ,3 ]
机构：
[1] Northeast Agr Univ, Coll Vet Med, Harbin 150030, Heilongjiang, Peoples R China
[2] Chinese Acad Agr Sci, Harbin Vet Res Inst, State Key Lab Vet Biotechnol, Harbin 150069, Heilongjiang, Peoples R China
[3] Heilongjiang Key Lab Anim Dis Control & Pharmaceu, Harbin 150030, Heilongjiang, Peoples R China
来源：
MICROBIAL PATHOGENESIS | 2019年 / 127卷
基金：
中国国家自然科学基金;
关键词：
Lactic acid bacteria; Biosurfactant; Antimicrobial activity; Anti-adhesive activity; Anti-Biofilm activity; Staphylococcus aureus; PSEUDOMONAS-AERUGINOSA; ADHESION;
D O I：
10.1016/j.micpath.2018.11.039
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Biosurfactants (BS) are amphipathic compounds produced by diverse groups of microorganisms exhibiting various biological activities. The current study aimed to assess antimicrobial, anti-adhesive and anti-biofilm activities of BS isolated from lactic acid bacteria (LAB), including Pediococcus acidilactici and Lactobacillus plantarum against Staphylococcus aureus CMCC 26003 in vitro. Cell-bound BS from both Pediococcus acidilactici and Lactobacillus plantarum were extracted, and their surface activities were evaluated by oil spreading assay. As quantified by crystal violet method, BS inhibited adhesion and biofilm formation of Staphylococcus aureus in a dose-dependent manner. The above findings were further supported by results of scanning electron microscopy. These two kinds of BS affect expressions of biofilm-related genes (cidA, icaA, dltB, agrA, sortaseA and sarA) and interfere with the release of signaling molecules (AI-2) in quorum sensing systems. Biological activities observed for BS produced by tested LAB suggest prospects for their use against Staphylococcus aureus biofilm-related infections.
引用
收藏
页码：12 / 20
页数：9
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