Immune reconstitution inflammatory syndrome: more answers, more questions

被引：193
作者：
Shelburne, SA
Montes, M
Hamill, RJ
机构：
[1] Baylor Coll Med, Dept Med, Infect Dis Sect, Houston, TX 77030 USA
[2] Michael E DeBakey Vet Affairs Med Ctr, Dept Med, Sect Infect Dis 111G, Houston, TX 77030 USA
来源：
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY | 2006年 / 57卷 / 02期
关键词：
HIV; HAART; paradoxical reaction; restoration;
D O I：
10.1093/jac/dki444
中图分类号：
R51 [传染病];
学科分类号：
100401 ;
摘要：
The institution of highly active antiretroviral therapy (HAART) in HIV-infected patients restores protective immune responses against a wide variety of pathogens and dramatically decreases mortality. In a subset of patients receiving HAART, immune reconstitution is associated with a pathological inflammatory response leading to substantial short-term morbidity and even mortality. The past several years have seen marked advances in our clinical understanding of the immune reconstitution inflammatory syndrome (IRIS), but many questions remain. This article summarizes recent data on clinical risk factors for the development of IRIS. A consistent finding from multiple groups is that IRIS develops in a substantial percentage of HIV-infected patients who have an underlying opportunistic infection and receive HAART. As the use of HAART stands to markedly increase over the next several years, optimal care of patients receiving HAART will need to incorporate monitoring for and treating complications of IRIS.
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收藏
页码：167 / 170
页数：4
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