Preparation of a 1:1 cocrystal of genistein with 4,4′-bipyridine

被引：36

作者：

Zhang, Yu-Nan ^{[1
]}

Yin, He-Mei ^{[1
]}

Zhang, Yu ^{[1
]}

Zhang, Da-Jun ^{[1
]}

Su, Xin ^{[1
]}

Kuang, Hai-Xue ^{[2
]}

机构：

[1] Jiamusi Univ, Inst Pharm Heilongjiang Prov, Jiamusi 154007, Heilongjiang Pr, Peoples R China

[2] Heilongjiang Univ Chinese Med, Harbin 150040, Heilongjiang Pr, Peoples R China

来源：

JOURNAL OF CRYSTAL GROWTH | 2017年 / 458卷

基金：

中国博士后科学基金;

关键词：

Cocrystal; X-ray diffraction; Crystal structure; Growth from solutions; Organic compounds; SOLID-STATE CHARACTERIZATION; PHARMACEUTICAL COCRYSTAL; INCLUSION COMPLEXES; SOLUBILITY; CYCLODEXTRINS; FLAVONOIDS; MYRICETIN; BIOAVAILABILITY; FORMULATION; STABILITY;

D O I：

10.1016/j.jcrysgro.2016.10.084

中图分类号：

O7 [晶体学];

学科分类号：

0702 ; 070205 ; 0703 ; 080501 ;

摘要：

Based on analysing the relationship between the possible number of intermolecular O-H center dot center dot center dot N hydrogen bonds and the stoichiometric ratio, a 1:1 C15H10O5 center dot C10H8N2 (genistein-4,4'-bipyridine) cocrystal has been prepared by solution evaporation and characterized. This work successfully demonstrates that the stoichiometric ratio could be inferred by analysing the possible number of intermolecular hydrogen bonds between flavonoids and amines. The strategy provides a facile route for rational designing cocrystal of flavonoids with amines. Additionally, the title cocrystal shows advantages in terms of solubility and antibacterial properties in comparison to pure genistein.

引用

页码：103 / 109

页数：7

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